Lack of association between Helicobacter pylori infection and extracardiac atherosclerosis in dyspeptic elderly subjects.
BACKGROUND: There are conflicting data on the association between Helicobacter pylori (HP) infection and cardiovascular diseases. AIM: To determine if there is an association between gastric HP infection and atherosclerosis of cerebral or peripheral arteries in elderly subjects. METHODS: 90 dyspepti...
| Publicado en: | Age & Ageing Vol. 28; no. 4; pp. 367 - 372 |
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| Autores principales: | , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Oxford University Press / USA
Jul99
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=107225393&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 107225393 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00020729 AGA jtl: Age & Ageing issn: 00020729 maglogo: N pubinfo: dt: Jul99 vid: 28 iid: 4 pid: 622 pub: Oxford University Press / USA artinfo: ui: 107225393 107225393 1999070932 10.1093/ageing/28.4.367 NLM10459790 107225393 ppf: 367 ppct: 5 formats: tig: atl: Lack of association between Helicobacter pylori infection and extracardiac atherosclerosis in dyspeptic elderly subjects. aug: au: Pilotto A Rumor F Franceschi M Leandro G Novello R Soffiati G Scagnelli M Di Mario F Valerio G affil: Division of Geriatric Medicine, S. Bortolo Hospital, Via Rodolfi 37, 36100 Vicenza, Italy sug: subj: Helicobacter Infections In Old Age Helicobacter Pylori In Old Age Gastrointestinal System Pathology Arteriosclerosis In Old Age Urease In Old Age Endoscopy, Gastrointestinal In Old Age Histology In Old Age Biopsy In Old Age Biopsy Classification Ultrasonography, Doppler In Old Age Arteries Ultrasonography Arteriosclerosis Diagnosis Cardiovascular Risk Factors In Old Age Pearson's Correlation Coefficient Comparative Studies Prospective Studies Descriptive Statistics Chi Square Test Yates' Continuity Correction Mann-Whitney U Test Logistic Regression Multivariate Analysis Odds Ratio Confidence Intervals Data Analysis Software Two-Tailed Test Aged Aged, 80 and Over Male Female Cross Sectional Studies Human Aged: 65+ years Aged, 80 & over Male Female ab: BACKGROUND: There are conflicting data on the association between Helicobacter pylori (HP) infection and cardiovascular diseases. AIM: To determine if there is an association between gastric HP infection and atherosclerosis of cerebral or peripheral arteries in elderly subjects. METHODS: 90 dyspeptic elderly subjects had upper gastro-intestinal endoscopy and the gastroduodenal pathology was identified. HP infection was confirmed by gastric histology and the rapid urease test. Vascular ultrasonography of extracranial cerebral arteries and leg arteries was performed to evaluate (i) the presence of an atherosclerotic lesion, (ii) the total length of all plaques documented and (iii) the number of arteries with atherosclerotic lesions. Statistical analysis was by the chi2 test, Yates's corrected chi2 test, the Mann-Whitney test and logistic regression. RESULTS: 59 subjects were HP-positive. These had a higher prevalence of peptic ulcer disease (P = 0.01) and higher serum levels of IgG anti-HP antibodies (P = 0.0001), but no significant differences in the number of atherosclerotic lesions, the total length of the plaques or the number of arteries with lesions. No significant association of HP positivity was found with diabetes mellitus, hypertension, cigarette smoking or coronary heart disease, nor with serum concentrations of HDL-cholesterol, fibrinogen, triglycerides or glucose. CONCLUSIONS: Elderly dyspeptic subjects with gastric HP infection had significantly more peptic ulcer disease but no more atherosclerotic lesions than those who were HP-negative. Atherosclerosis was not associated with HP infection. In this cross-sectional study of elderly patients with dyspepsia, no association between HP infection and extracardiac atherosclerosis was found. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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