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Aerobic exercise capacity remains normal despite impaired endothelial function in the micro- and macrocirculation of physically active IDDM patients.

The aim of the present study was to examine if diabetes in the absence of neuropathy affects the exercising capacity of IDDM patients, and whether regular, intense training has a beneficial effect on endothelial function. Five groups of subjects were studied: 23 healthy control subjects who exercise...

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Publicado en:Diabetes Vol. 46; no. 11; pp. 1846 - 1853
Autores principales: Veves A, Saouaf R, Donaghue VM, Mullooly CA, Kistler JA, Giurini JM, Horton ES, Fielding RA, Veves, A, Saouaf, R, Donaghue, V M, Mullooly, C A, Kistler, J A, Giurini, J M, Horton, E S, Fielding, R A
Formato: research tables/charts Journal Article
Publicado: American Diabetes Association Nov1997
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Nov1997
      vid: 46
      iid: 11
      pid: 1367
      pub: American Diabetes Association
      place: Arlington, Virginia
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        10.2337/diab.46.11.1846
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        atl: Aerobic exercise capacity remains normal despite impaired endothelial function in the micro- and macrocirculation of physically active IDDM patients.
      aug:
        au:
          Veves A
          Saouaf R
          Donaghue VM
          Mullooly CA
          Kistler JA
          Giurini JM
          Horton ES
          Fielding RA
          Veves, A
          Saouaf, R
          Donaghue, V M
          Mullooly, C A
          Kistler, J A
          Giurini, J M
          Horton, E S
          Fielding, R A
        affil: Department of Medicine, Deaconess-Joslin Foot Center, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
      sug:
        subj:
          Diabetes Mellitus, Type 1
          Aerobic Exercises
          Aerobic Capacity
          Diabetic Neuropathies Complications
          Experimental Studies
          Data Analysis, Statistical
          Data Analysis Software
          Kruskal-Wallis Test
          Analysis of Variance
          Diabetic Neuropathies Diagnosis
          Adult
          Male
          Female
          Funding Source
          Human
          Adult: 19-44 years
          Male
          Female
      ab: The aim of the present study was to examine if diabetes in the absence of neuropathy affects the exercising capacity of IDDM patients, and whether regular, intense training has a beneficial effect on endothelial function. Five groups of subjects were studied: 23 healthy control subjects who exercised regularly (age 33 +/- 6 years), 23 nonneuropathic type 1 diabetic patients who exercised regularly (age 33 +/- 6 years, IDDM duration 11 +/- 8 years), 7 neuropathic type 1 diabetic patients who exercised regularly (age 36 +/- 7 years, IDDM duration 22 +/- 8 years), 18 healthy subjects who did not exercise regularly (age 34 +/- 7 years), and 5 nonneuropathic type 1 diabetic patients who did not exercise regularly (age 31 +/- 4 years, IDDM duration 20 +/- 3 years). All groups were matched for age, sex, and body weight. No differences existed in the energy expenditure per week in physical activity among the three exercising groups or between the two nonexercising groups. The maximal oxygen uptake was similar between control and diabetic nonneuropathic exercisers, and among diabetic neuropathic exercisers, control nonexercisers, and diabetic nonexercisers; however, a significant difference existed between the first two and the last three groups (P < 0.0001). A stepwise increase was found in the resting heart rate among the groups, ranging from the lowest in control exercisers to the highest in diabetic nonexercisers, but the maximal heart rate was lower only in diabetic neuropathic exercisers compared with all other groups (P < 0.05). Assessments of endothelial function in both macro- and microcirculation were performed in 12 control exercisers, 10 diabetic nonneuropathic exercisers, 5 diabetic neuropathic exercisers, 17 control nonexercisers, and 4 diabetic nonexercisers. When all diabetic patients were considered as one group and all control subjects as another, the microcirculation endothelial function in the diabetic group was reduced compared with the control subjects (91 +/- 49 vs. 122 +/- 41% flux increase over baseline; P < 0.05). In contrast, no differences existed among the three diabetic groups or between the two control groups. Similarly, in macrocirculation, a reduced response during reactive hyperemia was observed in the diabetic patients compared with control subjects (7.0 +/- 4.5 vs. 11.2 +/- 6.6% diameter increase; P < 0.05), whereas again no difference existed among the three diabetic groups or between the two control groups. These data suggest that diabetes per se does not affect aerobic exercise capacity (VO2max) in physically active individuals, but is reduced in the presence of neuropathy. In addition, regular exercise training involving the lower extremities does not improve the endothelial function in the micro- and macrocirculation of the nonexercised upper extremity in type 1 diabetic patients.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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