Spectrum of AIDS-associated malignant disorders.
Background: To clarify which types of cancer result from AIDS, we compared the cancer experiences of people with AIDS with those of the general population by matching population-based cancer and AIDS registries in the USA and Puerto Rico.Methods: We used a probabilistic matching algorithm to compare...
| Published in: | Lancet Vol. 351; no. 9119; pp. 1833 - 1840 |
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| Main Authors: | , , , , , , , , , , , , , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Lancet
6/20/1998
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=107272220&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 107272220 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01406736 LAN jtl: Lancet issn: 01406736 maglogo: N pubinfo: dt: 6/20/1998 vid: 351 iid: 9119 pid: 1297 pub: Lancet place: Philadelphia, Pennsylvania artinfo: ui: 107272220 107272220 NLM9652666 1998042392 10.1016/s0140-6736(97)09028-4 NLM9652666 107272220 ppf: 1833 ppct: 7 formats: fmt: @attributes: type: T tig: atl: Spectrum of AIDS-associated malignant disorders. aug: au: Goedert JJ Cote TR Virgo P Scoppa SM Kingma DW Gail MH Jaffe ES Biggar RJ Goedert, J J Coté, T R Virgo, P Scoppa, S M Kingma, D W Gail, M H Jaffe, E S Biggar, R J affil: Viral Epidemiology Branch, National Cancer Institute, Rockville, MD, USA sug: subj: Neoplasms Epidemiology Acquired Immunodeficiency Syndrome Complications Confidence Intervals Relative Risk Registries, Disease United States Disease Surveillance Risk Factors Incidence Prevalence Epidemiological Research Sarcoma, Kaposi's Epidemiology Lymphoma, Non-Hodgkin's Epidemiology Funding Source Human ab: Background: To clarify which types of cancer result from AIDS, we compared the cancer experiences of people with AIDS with those of the general population by matching population-based cancer and AIDS registries in the USA and Puerto Rico.Methods: We used a probabilistic matching algorithm to compare names, birth dates, and, where available, social-security numbers of 98,336 people with AIDS and 1,125,098 people with cancer aged less than 70 years. We defined AIDS-related cancers as those with both significantly raised incidence post-AIDS and increasing prevalence from 5 years pre-AIDS to 2 years post-AIDS.Findings: Among people with AIDS, we found 7028 cases of Kaposi's sarcoma (KS), 1793 of non-Hodgkin lymphoma (NHL), and 712 other cases of histologically defined cancer. Incidence rates among people with AIDS were increased 310-fold for KS, 113-fold for NHL, and 1.9-fold (95% CI 1.5-2.3) for other cancers. Of 38 malignant disorders other than KS and NHL, only angiosarcoma (36.7-fold), Hodgkin's disease (7.6-fold), multiple myeloma (4.5-fold), brain cancer (3.5-fold), and seminoma (2.9-fold) were raised and increasing significantly (p<0.02) from the pre-AIDS to the post-AIDS period.Interpretation: Interpretation is complicated by screening and shared risk factors, such as sexual behaviour and cigarette smoking. However, our data indicate that AIDS leads to a significantly increased risk of Hodgkin's disease, multiple myeloma, brain cancer, and seminoma. Immunological failure to control herpes or other viral infections may contribute to these malignant diseases. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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