1996 Sheldon Berrol, MD Senior Lectureship: prospects for improving outcome by research... this article is based on a presentation delivered at the 15th Annual Conference of the Brain Injury Association (formerly National Head Injury Foundation), November 5, 1996, in Dallas, TX.

Some of the major clinical advances in treatment of acute brain injury are discussed chronologically. These advances have resulted in a progressive decrease in mortality rate of patients with severe brain injury since 1975. Most of these improvements in care have been recently incorporated into a gu...

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Publicado en:Journal of Head Trauma Rehabilitation Vol. 12; no. 5; pp. 88 - 93
Autor principal: Clifton GI
Formato: standards tables/charts Journal Article
Publicado: Lippincott Williams & Wilkins 1997 Oct
Acceso en línea:Ver este registro en EBSCOhost
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      dt: 1997 Oct
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      pub: Lippincott Williams & Wilkins
      place: Baltimore, Maryland
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        atl: 1996 Sheldon Berrol, MD Senior Lectureship: prospects for improving outcome by research... this article is based on a presentation delivered at the 15th Annual Conference of the Brain Injury Association (formerly National Head Injury Foundation), November 5, 1996, in Dallas, TX.
      aug:
        au: Clifton GI
        affil: Professor and Chairman, Department of Neurosurgery, Vivian L. Smith Center for Neurologic Research, University of Texas-Houston Medical School, 6431 Fannin, Suite 7.148, Houston, TX 77030
      sug:
        subj:
          Brain Injuries
          Brain Injuries Therapy
          Outcomes Research
          Trauma
          Mortality
          Practice Guidelines
          Clinical Trials
          Intracranial Hypertension
      ab: Some of the major clinical advances in treatment of acute brain injury are discussed chronologically. These advances have resulted in a progressive decrease in mortality rate of patients with severe brain injury since 1975. Most of these improvements in care have been recently incorporated into a guidelines document for acute care, which has received broad organizational support. Animal models of brain injury, in which behavioral outcome could be used to test early therapy, became available in 1985. To date, completed multicenter clinical trials of early therapy to block the biochemical cascade after injury derived from these models have been negative. A number of ongoing trials are not yet completed, however. The potential reasons for negative results are discussed. Copyright (c) 1997 by Aspen Publishers, Inc.
      pubtype: Academic Journal
      doctype:
        standards
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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