Effect of acid suppression on efficacy of treatment for Helicobacter pylori infection.
Eradication of Helicobacter pylori from the stomach by triple therapy with bismuth, tetracycline, and metronidazole cures peptic ulcer disease. We investigated whether concomitant acid inhibition with omeprazole would improve the results of triple therapy. 108 consecutive patients with peptic-ulcer...
| Publicado en: | Lancet Vol. 345; no. 8953; pp. 817 - 821 |
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| Autores principales: | , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Lancet
4/1/1995
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=107378404&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 107378404 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01406736 LAN jtl: Lancet issn: 01406736 maglogo: N pubinfo: dt: 4/1/1995 vid: 345 iid: 8953 pid: 1297 pub: Lancet place: Philadelphia, Pennsylvania artinfo: ui: 107378404 107378404 NLM7898228 1996025403 10.1016/s0140-6736(95)92962-2 NLM7898228 107378404 ppf: 817 ppct: 4 formats: fmt: @attributes: type: T tig: atl: Effect of acid suppression on efficacy of treatment for Helicobacter pylori infection. aug: au: de Boer W Driessen W Jansz A Tytgat G de Boer, W Driessen, W Jansz, A Tytgat, G affil: Department of Internal Medicine, Sint Joseph Ziekenhuis, Veldhoven, Netherlands sug: subj: Helicobacter Pylori Helicobacter Infections Drug Therapy Peptic Ulcer Drug Therapy Omeprazole Administration and Dosage Antiulcer Agents Administration and Dosage Comparative Studies Female Male Adult Middle Age Aged Prospective Studies Drug Therapy, Combination Antiulcer Agents Adverse Effects Time Factors Drug Administration Schedule Human Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Female Male ab: Eradication of Helicobacter pylori from the stomach by triple therapy with bismuth, tetracycline, and metronidazole cures peptic ulcer disease. We investigated whether concomitant acid inhibition with omeprazole would improve the results of triple therapy. 108 consecutive patients with peptic-ulcer disease and biopsy-proven H pylori infection were randomised to 7 days of triple therapy with or without omeprazole 20 mg twice daily. Patients in the omeprazole-treated group were pretreated with 3 days of omeprazole. Eradication of H pylori was assessed by 10 endoscopic biopsies for urease test, histology, and culture 4-6 weeks after treatment. 53 of 54 (98.1%) patients treated with omeprazole were cured compared with 45 of 54 (83.3%) of those not treated (p = 0.02), a difference in efficacy of 14.8% (95% Cl 4.2-25.4%). Most side effects were mild and did not interfere with compliance; 105 patients (97.2%) finished treatment. Gastro-intestinal side effects were significantly fewer in the omeprazole group. We conclude that the addition of omeprazole to triple therapy improves efficacy, lessens side effects, and is sufficiently efficacious to obviate the need for a diagnostic test of cure in compliant patients. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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