Modern diet and metabolic variance--a recipe for disaster?
Objective: Recently, a positive correlation between alanine transaminase activity and body mass was established among healthy young individuals of normal weight. Here we explore further this relationship and propose a physiological rationale for this link.Design: Cross-sectional statistical analysis...
| Publicado en: | Nutrition Journal Vol. 13; pp. 15 - 16 |
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| Autores principales: | , , , |
| Formato: | research Journal Article |
| Publicado: |
BioMed Central
2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=107789937&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 107789937 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14752891 1CYY jtl: Nutrition Journal issn: 14752891 maglogo: N pubinfo: dt: 2014 vid: 13 pid: 24147 pub: BioMed Central artinfo: ui: 107789937 107789937 NLM24502225 2012475203 10.1186/1475-2891-13-15 NLM24502225 PMC3923254 107789937 ppf: 15 ppct: 1 formats: fmt: @attributes: type: P tig: atl: Modern diet and metabolic variance--a recipe for disaster? aug: au: Grantham, James P Staub, Kaspar Rühli, Frank J Henneberg, Maciej affil: School of Medical Sciences, The University of Adelaide, Lincoln College, 45 Brougham Place, Adelaide 5006, SA, Australia. james.grantham@student.adelaide.edu.au. sug: subj: Adipose Tissue Distribution Alanine Aminotransferase Blood Body Mass Index Diet Obesity Physiopathology Adult Blood Glucose Metabolism Cross Sectional Studies Energy Metabolism Physiology Food Habits Human Arctic Peoples Male Obesity Complications Postprandial Period Adult: 19-44 years Male ab: Objective: Recently, a positive correlation between alanine transaminase activity and body mass was established among healthy young individuals of normal weight. Here we explore further this relationship and propose a physiological rationale for this link.Design: Cross-sectional statistical analysis of adiposity across large samples of adults differing by age, diet and lifestyle.Subjects: 46,684 19-20 years old Swiss male conscripts and published data on 1000 Eskimos, 518 Toronto residents and 97,000 North American Adventists.Measurements: Serum concentrations of the alanine transaminase, post-prandial glucose levels, cholesterol, body height and weight, blood pressure and routine blood analysis (thrombocytes and leukocytes) for Swiss conscripts. Adiposity measures and dietary information for other groups were also obtained.Results: Stepwise multiple regression after correction for random errors of physiological tests showed that 28% of the total variance in body mass is associated with ALT concentrations. This relationship remained significant when only metabolically healthy (as defined by the American Heart Association) Swiss conscripts were selected. The data indicated that high protein only or high carbohydrate only diets are associated with lower levels of obesity than a diet combining proteins and carbohydrates.Conclusion: Elevated levels of alanine transaminase, and likely other transaminases, may result in overactivity of the alanine cycle that produces pyruvate from protein. When a mixed meal of protein, carbohydrate and fat is consumed, carbohydrates and fats are digested faster and metabolised to satisfy body's energetic needs while slower digested protein is ultimately converted to malonyl CoA and stored as fat. Chronicity of this sequence is proposed to cause accumulation of somatic fat stores and thus obesity. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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