Effect of two dietary fibers on satiety and glycemic parameters: a randomized, double-blind, placebo-controlled, exploratory study.
Background: Dietary carbohydrates may affect metabolic and physiologic parameters. The present study evaluated whether a combination of two dietary fibers, oligofructose (OFS) and pectin (P), altered satiety and glycemic parameters. The primary objective of this study was to determine whether dietar...
| Publicado en: | Nutrition Journal Vol. 13; pp. 45 - 46 |
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| Autores principales: | , , , , |
| Formato: | research randomized controlled trial Journal Article |
| Publicado: |
BioMed Central
2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=107794919&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 107794919 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14752891 1CYY jtl: Nutrition Journal issn: 14752891 maglogo: N pubinfo: dt: 2014 vid: 13 pid: 24147 pub: BioMed Central artinfo: ui: 107794919 107794919 NLM24886409 2012607490 10.1186/1475-2891-13-45 NLM24886409 PMC4046024 107794919 ppf: 45 ppct: 1 formats: fmt: @attributes: type: P tig: atl: Effect of two dietary fibers on satiety and glycemic parameters: a randomized, double-blind, placebo-controlled, exploratory study. aug: au: Savastano, David M Hodge, Rebecca J Nunez, Derek J Walker, Ann Kapikian, Roxanne affil: Discovery Medicine, GlaxoSmithKline, Five Moore Drive, MS N2-3208, Research Triangle Park, NC 27709, USA. rebecca.j.hodge@gsk.com. sug: subj: Blood Glucose Drug Effects Dietary Fiber Administration and Dosage Oligosaccharides Administration and Dosage Polysaccharides Administration and Dosage Adult Appetite Drug Effects Dietary Fiber Pharmacodynamics Double-Blind Studies Energy Intake Drug Effects Female Human Male Middle Age Obesity Drug Therapy Oligosaccharides Pharmacodynamics Obesity Polysaccharides Pharmacodynamics Satiation Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: Background: Dietary carbohydrates may affect metabolic and physiologic parameters. The present study evaluated whether a combination of two dietary fibers, oligofructose (OFS) and pectin (P), altered satiety and glycemic parameters. The primary objective of this study was to determine whether dietary supplementation for 3 weeks with OFS + P would produce a greater reduction in energy intake of an ad libitum test meal compared to control.Methods: This was a single center, randomized, double-blind, placebo-controlled, parallel group study in overweight and obese, otherwise healthy, subjects (N = 96). There were two OFS + P treatment groups: high-dose (30 g/d), low-dose (15 g/d), and a control group (maltodextrin 15 g/d). Energy intake, appetite measures based on Satiety Labeled Intensity Magnitude (SLIM) scale, fasting and post-prandial glucose, and insulin levels and body weight were measured at baseline and at the end of 3 weeks. Adverse events and gastrointestinal tolerability of the treatments were also assessed.Results: An analysis of covariance (ANCOVA) performed on the primary endpoint change from baseline in energy intake, showed no statistically significant difference in energy intake among the three treatment groups (p = 0.5387). The LS mean changes (SE) in energy intake from baseline to week 3 were -58.3 (42.4) kilocalories (kcal) for the high dose group, -74.2 (43.6) kcal for the low dose group, and -9.0 (42.9) kcal for the control group. For the pairwise comparisons of OFS + P doses and control, confidence intervals were constructed around the difference in LS mean changes. All study products were generally well tolerated.Conclusion: There was a directional benefit in ad libitum energy intake for both OFS + P doses compared to control, with a greater reduction in kilocalories in the low dose comparison, but the reductions were not significant. Further studies are warranted.Clinical Trial Registration: GSK Clinical Study Register # W7781293. pubtype: Academic Journal doctype: research randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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