Extended first-trimester screening using multiple sonographic markers and maternal serum biochemistry: a five-year prospective study.
Objective: To examine the performance of first-trimester screening test combining several fetal sonographic and maternal biochemical markers for major aneuploidy in a Chinese population. Methods: This was a prospective study performed over 5 years between January 2005 and December 2010 in Taiwan, wi...
| Publicado en: | Fetal Diagnosis & Therapy Vol. 35; no. 4; pp. 296 - 302 |
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| Autores principales: | , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Karger AG
2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=107795581&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 107795581 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10153837 NIP jtl: Fetal Diagnosis & Therapy issn: 10153837 maglogo: N pubinfo: dt: 2014 vid: 35 iid: 4 pid: 2485 pub: Karger AG artinfo: ui: 107795581 107795581 NLM24503519 2012622282 10.1159/000357564 NLM24503519 107795581 ppf: 296 ppct: 6 formats: tig: atl: Extended first-trimester screening using multiple sonographic markers and maternal serum biochemistry: a five-year prospective study. aug: au: Hsiao, Ching-Hua Cheng, Po-Jen Shaw, S W Steven Hsu, Jenn-Jeih Chen, Ran-Chou Tseng, Yin-Jiun Chu, Woei-Chyn affil: Department of Obstetrics and Gynecology, Taipei City Hospital, Women and Children Campus, Taipei, Taiwan, ROC. sug: subj: Gonadotropins, Chorionic Blood Nuchal Translucency Measurement Pregnancy Proteins Metabolism Chromosome Disorders Diagnosis Adult Algorithms Female Human Karyotyping Nasal Bone Ultrasonography Pregnancy Pregnancy Trimester, First Prospective Studies Blood Circulation Sensitivity and Specificity Software Adult: 19-44 years Female ab: Objective: To examine the performance of first-trimester screening test combining several fetal sonographic and maternal biochemical markers for major aneuploidy in a Chinese population. Methods: This was a prospective study performed over 5 years between January 2005 and December 2010 in Taiwan, with 20,586 cases that had a combination of a variety of sonographic markers and maternal serological β-human chorionic gonadotropin and pregnancy-associated plasma protein-A levels assessed at first trimester screening between 11(+0) and 13(+6) weeks of gestation. The risk of aneuploidy was calculated using algorithm software developed by Fetal Medicine Foundation, London. Fetal karyotyping was performed when the prenatal screening showed a risk of 1/300 or higher. All cases were followed for fetal outcome. Results: The study population was divided into four groups according to the screening strategy performed. The combination of maternal serological biochemistry and nuchal translucency measurement had a 66.7% detection rate of trisomy 21. Addition of nasal bone status increased the detection rate of trisomy 21 to 88.2%. Inclusion of tricuspid regurgitation flow showed an 87.5% detection rate of trisomy 21. Further inclusion of ductus venosus flow increased the detection rate of trisomy 21 to 100%. Incorporating more markers greatly increased the detection rate and decreased the false-positive rate (FPR). Conclusion: Extension of first-trimester screening to include more sonographic markers greatly increased the sensitivity and decreased FPR for detection of chromosomal abnormalities. Such screening strategy is effective in clinical practice for the Chinese ethnic population. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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