Accuracy of GastroPanel for the diagnosis of atrophic gastritis.
Background: It has been suggested that GastroPanel might be a useful tool for the diagnosis of chronic atrophic gastritis (CAG) measuring four biomarkers in blood: basal gastrin-17 (G17), pepsinogen I and II (PGI and PGII), and Helicobacter pylori antibodies.Aim: To determine the accuracy of GastroP...
| Publicado en: | European Journal of Gastroenterology & Hepatology Vol. 26; no. 9; pp. 941 - 949 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
2014 Sep
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=107797950&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 107797950 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0954691X 8CE jtl: European Journal of Gastroenterology & Hepatology issn: 0954691X maglogo: N pubinfo: dt: 2014 Sep vid: 26 iid: 9 pid: 5086 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 107797950 107797950 NLM25014624 2012666405 10.1097/MEG.0000000000000132 NLM25014624 PMC4232299 107797950 ppf: 941 ppct: 8 formats: tig: atl: Accuracy of GastroPanel for the diagnosis of atrophic gastritis. aug: au: McNicholl, Adrian G Forné, Montserrat Barrio, Jesus De la Coba, Cristobal González, Begoña Rivera, Robin Esteve, Maria Fernandez-Bañares, Fernando Madrigal, Beatriz Gras-Miralles, Beatriz Perez-Aisa, Angeles Viver-Pi-Sunyer, Jose M Bory, Felipe Rosinach, Merce Loras, Carmen Esteban, Carlos Santolaria, Santos Gomollon, Fernando Valle, Julio Gisbert, Javier P sug: subj: Biological Markers Blood Gastritis, Atrophic Diagnosis Adult Algorithms Antibodies, Bacterial Blood Biopsy Chronic Disease Double-Blind Studies Female Gastritis, Atrophic Microbiology Helicobacter Infections Complications Helicobacter Pylori Immunology Human Male Middle Age Enzymes Blood Predictive Value of Tests Prospective Studies Pyloric Antrum Pathology Stomach Pathology Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: Background: It has been suggested that GastroPanel might be a useful tool for the diagnosis of chronic atrophic gastritis (CAG) measuring four biomarkers in blood: basal gastrin-17 (G17), pepsinogen I and II (PGI and PGII), and Helicobacter pylori antibodies.Aim: To determine the accuracy of GastroPanel for the diagnosis of CAG.Methods: This was a prospective, blinded, multicenter study that included dyspeptic patients. G17, PGI, and PGII were determined by enzyme immunoassays. Three antrum and two corpus biopsies were obtained for standard histological analysis and rapid urease test. Biopsies were analyzed by a single blinded expert pathologist.Results: Ninety-one patients were included (77% women, mean age 44 years, 51% H. pylori positive, 17% with CAG). G17 was reduced in patients with antrum CAG (5.4 vs. 13.4 pmol/l; P<0.01) and increased in patients with corpus CAG (11 vs. 24 pmol/l; P<0.05), but its accuracy was only acceptable in the case of corpus localization [area under the receiver operating characteristic curve (AUC), 74%]; PGII difference was almost statistically significant only when testing for corpus atrophy (33 vs. 21 μg/l; P=0.05; AUC=72%). The PGI and PGI/PGII ratio showed no significant differences (AUCs were all unacceptably low). Helicobacter pylori antibody levels were higher in H. pylori-infected patients (251 vs. 109 EIU, P=0.01; AUC=70). The accuracy of GastroPanel for the diagnosis of CAG was as follows: sensitivity 50%; specificity 80%; positive 25% and negative 92% predictive values; and positive 2.4 and negative 0.6 likelihood ratios.Conclusion: GastroPanel is not accurate enough for the diagnosis of CAG; thus, its systematic use in clinical practice cannot be recommended. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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