Brain fluorodeoxyglucose PET in adrenoleukodystrophy.
Objective: To investigate the cerebral glucose metabolism in subjects with X-linked adrenoleukodystrophy (X-ALD) by using brain [(18)F]-fluorodeoxyglucose PET (FDG-PET). Methods: Cross-sectional study in which 12 adults with various forms of X-ALD underwent clinical evaluation and brain MRI, followe...
| Publicado en: | Neurology Vol. 83; no. 11; pp. 981 - 990 |
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| Autores principales: | , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
9/9/2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=107817144&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 107817144 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283878 NRO jtl: Neurology issn: 00283878 maglogo: N pubinfo: dt: 9/9/2014 vid: 83 iid: 11 pid: 433 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 107817144 107817144 NLM25098542 2012714918 10.1212/WNL.0000000000000770 NLM25098542 107817144 ppf: 981 ppct: 9 formats: tig: atl: Brain fluorodeoxyglucose PET in adrenoleukodystrophy. aug: au: Salsano, Ettore Marotta, Giorgio Manfredi, Valentina Giovagnoli, Anna Rita Farina, Laura Savoiardo, Mario Pareyson, Davide Benti, Riccardo Uziel, Graziella affil: From the Departments of Clinical Neurosciences (E.S., D.P.), Diagnostics and Applied Technology (V.M., A.R.G., L.F., M.S.), and Child Neurology (G.U.), Fondazione IRCCS, Istituto Neurologico 'C. Besta,' Milano, Italy; and Department of Nuclear Medicine (G.M., R.B.), Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy. ettore.salsano@istituto-besta.it. sug: subj: Adrenoleukodystrophy Metabolism Adrenoleukodystrophy Radiography Brain Metabolism Brain Radiography Glucose Metabolism Adult Brain Mapping Methods Cross Sectional Studies Fludeoxyglucose F 18 Diagnostic Use Human Image Processing, Computer Assisted Methods Male Middle Age Neuropsychological Tests Personality Personality Assessment Tomography, Emission-Computed Psychological Tests Radiopharmaceuticals Diagnostic Use Software Young Adult Adult: 19-44 years Middle Aged: 45-64 years Male ab: Objective: To investigate the cerebral glucose metabolism in subjects with X-linked adrenoleukodystrophy (X-ALD) by using brain [(18)F]-fluorodeoxyglucose PET (FDG-PET). Methods: Cross-sectional study in which 12 adults with various forms of X-ALD underwent clinical evaluation and brain MRI, followed by brain FDG-PET, neuropsychological assessment, and personality and psychopathology evaluation using the Symptom Checkist-90-Revised (SCL-90-R) and the Millon Clinical Multiaxial Inventory-III (MCMI-III). Results: When compared to healthy control subjects (n = 27) by using Statistical Parametric Mapping 8 software, the patients with X-ALD-with or without brain MRI changes-showed a pattern of increased glucose metabolism in frontal lobes and reduced glucose metabolism in cerebellum and temporal lobe areas. On single case analysis by Scenium software, we found a similar pattern, with significant (p < 0.02) correlation between the degree of hypermetabolism in the frontal lobes of each patient and the corresponding X-ALD clinical scores. With respect to personality, we found that patients with X-ALD usually present with an obsessive-compulsive personality disorder on the MCMI-III, with significant (p < 0.05) correlation between glucose uptake in ventral striatum and severity of score on the obsessive-compulsive subscale. Conclusions: We examined cerebral glucose metabolism using FDG-PET in a cohort of patients with X-ALD and provided definite evidence that in X-ALD the analysis of brain glucose metabolism reveals abnormalities independent from morphologic and signal changes detected by MRI and related to clinical severity. Brain FDG-PET may be a useful neuroimaging technique for the characterization of X-ALD and possibly other leukodystrophies. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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