Initial cognitive decline is associated with cortical thinning in early Parkinson disease.
Objectives: Our aim was to assess cortical thickness in a large multicenter cohort of drug-naive patients with early Parkinson disease (PD), with and without mild cognitive impairment (MCI), and explore the cognitive correlates of regional cortical thinning.Methods: One hundred twenty-three newly di...
| Publicado en: | Neurology Vol. 82; no. 22; pp. 2017 - 2026 |
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| Autores principales: | , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
6/3/2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=107853946&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 107853946 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283878 NRO jtl: Neurology issn: 00283878 maglogo: N pubinfo: dt: 6/3/2014 vid: 82 iid: 22 pid: 433 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 107853946 107853946 NLM24808018 2012603000 10.1212/WNL.0000000000000483 NLM24808018 PMC4105257 107853946 ppf: 2017 ppct: 9 formats: tig: atl: Initial cognitive decline is associated with cortical thinning in early Parkinson disease. aug: au: Pereira, Joana B Svenningsson, Per Weintraub, Daniel Brønnick, Kolbjørn Lebedev, Alexander Westman, Eric Aarsland, Dag affil: From the Department of Neurobiology, Care Sciences and Society (J.B.P., E.W.), and Centre for Alzheimer's Disease Research, Department of Neurobiology, Care Sciences and Society (D.A.), Karolinska Institutet, Stockholm; Centre for Molecular Medicine (P.S.), Department of Neurology and Clinical Neuroscience, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden; Department of Psychiatry and Neurology (D.W.), Perelman School of Medicine at the University of Pennsylvania, Philadelphia VA Medical Center; and The Norwegian Center for Movement Disorders (K.B.), and Centre for Age-Related Medicine, Department of Psychiatry (A.L., D.A.), Stavanger University Hospital, Stavanger, Norway. joana.pereira@ki.se. sug: subj: Cerebral Cortex Pathology Magnetic Resonance Imaging Methods Cognition Disorders Parkinson Disease Pathology Aged Atrophy Biological Markers Cerebral Cortex Physiopathology Female Geriatric Assessment Human Magnetic Resonance Imaging Equipment and Supplies Male Middle Age Cognition Disorders Diagnosis Cognition Disorders Physiopathology Neuropsychological Tests Parkinson Disease Classification Parkinson Disease Physiopathology Aged: 65+ years Middle Aged: 45-64 years Female Male ab: Objectives: Our aim was to assess cortical thickness in a large multicenter cohort of drug-naive patients with early Parkinson disease (PD), with and without mild cognitive impairment (MCI), and explore the cognitive correlates of regional cortical thinning.Methods: One hundred twenty-three newly diagnosed patients with PD and 56 healthy controls with 3-tesla structural MRI scans and complete neuropsychological assessment from the Parkinson's Progression Markers Initiative were included. Modified Movement Disorders Society Task Force level II criteria were applied to diagnose MCI in PD. FreeSurfer image processing and analysis software was used to measure cortical thickness across groups and the association with cognitive domains and tests.Results: In patients with MCI, atrophy was found in temporal, parietal, frontal, and occipital areas compared with controls. Specific regional thinning in the right inferior temporal cortex was also found in cognitively normal patients. Memory, executive, and visuospatial performance was associated with temporoparietal and superior frontal thinning, suggesting a relationship between cognitive impairment and both anterior and posterior cortical atrophy in the whole patient sample.Conclusions: These findings confirm that MCI is associated with widespread cortical atrophy. In addition, they suggest that regional cortical thinning is already present at the time of diagnosis in patients with early, untreated PD who do not meet the criteria for MCI. Together, the results indicate that cortical thinning can serve as a marker for initial cognitive decline in early PD. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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