Comparison of Ethyl Glucuronide and Carbohydrate-Deficient Transferrin in Different Body Fluids for Post-mortem Identification of Alcohol Use.
AIMS: Alcohol abuse is a major risk factor for premature death. Confirming the role of alcohol consumption in cause-of-death investigations has, however, remained difficult, due to lack of reliable biomarkers. METHODS: We compared ethyl glucuronide (EtG) and carbohydrate-deficient transferrin (CDT)...
| Published in: | Alcohol & Alcoholism Vol. 49; no. 1; pp. 55 - 60 |
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| Main Authors: | , , , , , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Oxford University Press / USA
Jan/Feb2014
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=107880285&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 107880285 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07350414 FA3 jtl: Alcohol & Alcoholism issn: 07350414 maglogo: N pubinfo: dt: Jan/Feb2014 vid: 49 iid: 1 pid: 622 pub: Oxford University Press / USA artinfo: ui: 107880285 93730154 10.1093/alcalc/agt159 NLM24154730 107880285 ppf: 55 ppct: 5 formats: fmt: @attributes: type: P tig: atl: Comparison of Ethyl Glucuronide and Carbohydrate-Deficient Transferrin in Different Body Fluids for Post-mortem Identification of Alcohol Use. aug: au: Rainio, Juha Ahola, Sanna Kangastupa, Päivikki Kultti, Johanna Tuomi, Heidi Karhunen, Pekka J. Helander, Anders Niemelä, Onni affil: Department of Forensic Medicine, School of Medicine, University of Tampere, 33014 Tampere, Finland sug: subj: Transferrin Classification Body Fluids Alcohol Drinking Evaluation Alcohol Abuse Postmortem Care Evaluation Human Comparative Studies T-Tests Nonparametric Statistics Mann-Whitney U Test Pearson's Correlation Coefficient Spearman's Rank Correlation Coefficient ROC Curve Data Analysis Software ab: AIMS: Alcohol abuse is a major risk factor for premature death. Confirming the role of alcohol consumption in cause-of-death investigations has, however, remained difficult, due to lack of reliable biomarkers. METHODS: We compared ethyl glucuronide (EtG) and carbohydrate-deficient transferrin (CDT) assays from serum, urine, cerebrospinal fluid and vitreous humor in a forensic autopsy population with either a positive (n = 38) or negative (n = 22) history of alcohol abuse based on detailed medical and police records and forensic toxicological investigations. RESULTS: A positive blood alcohol concentration (median 1.15, range 0-3.3) was found in 26/38 (68%) of the cases with a documented history of alcohol abuse. EtG concentrations (mean ± SD) in urine (339 ± 389 mg/l, P < 0.001), vitreous humor (4.2 ± 4.8 mg/l, P < 0.001), serum (6.9 ± 8.9 mg/l, P < 0.01) and cerebrospinal fluid (1.7 ± 2.7 mg/l, P < 0.01) were significantly higher among the cases with a positive history of alcohol use than those in the alcohol-history negative group, whereas in corresponding comparisons CDT was significantly different only in cerebrospinal fluid (4.3 ± 2.1 vs. 2.3 ± 0.6%, P < 0.05). The highest sensitivities (92%) in detecting ante-mortem alcohol use were obtained for urine and vitreous humor EtG assays. CONCLUSION: Our data indicate that measurements of EtG in urine or vitreous humor show the highest diagnostic accuracies in post-mortem investigations of excessive alcohol consumption and can be recommended for routine applications. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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