Gleason 6 Prostate Cancer: Serious Malignancy or Toothless Lion?
Autopsy studies of men without known prostate cancer suggest that a substantial reservoir of prostate cancer that does not cause symptoms or death exists within the population. The majority of these cancers are Gleason 6 tumors and are frequently detected by prostate-specific antigen-based pros-tate...
| Publicado en: | Oncology (08909091) Vol. 28; no. 1; pp. 16 - 23 |
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| Autores principales: | , |
| Formato: | Journal Article |
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MJH Life Sciences
Jan2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=107884775&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 107884775 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 08909091 YYT jtl: Oncology (08909091) issn: 08909091 maglogo: N pubinfo: dt: Jan2014 vid: 28 iid: 1 pid: 54670 pub: MJH Life Sciences place: Cranbury, New Jersey artinfo: ui: 107884775 2012465057 107884775 ppf: 16 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Gleason 6 Prostate Cancer: Serious Malignancy or Toothless Lion? aug: au: Lepor, Herbert Donin, Nicholas M. affil: Department of Urology, NYU Langone Medical Center, New York University School of Medicine, New York, New York; Department of Pharmacology, NYU Langone Medical Center, New York University School of Medicine; Smilow Comprehensive Prostate Cancer Center, NYU Langone Medical Center, New York University School of Medicine sug: subj: Prostatic Neoplasms Prognosis Neoplasm Staging Prostatic Neoplasms Diagnosis Prostatic Neoplasms Therapy Cancer Screening Prostate-Specific Antigen Disease Progression Neoplasm Metastasis Biopsy ab: Autopsy studies of men without known prostate cancer suggest that a substantial reservoir of prostate cancer that does not cause symptoms or death exists within the population. The majority of these cancers are Gleason 6 tumors and are frequently detected by prostate-specific antigen-based pros-tate cancer screening. There is strong evidence from longitudinal cohort studies of men with both treated and untreated Gleason 6 prostate cancer to suggest that Gleason 6 disease, when not associated with higher-grade cancer, virtually never demonstrates the ability to metastasize and thus represents an indolent entity that does not require treatment. Whether Gleason 6 has a propensity to progress to higher-grade cancer is still under investigation. Because the term 'cancer' has historically been used to represent a disease state that leads to progressive illness that is uniformly fatal without treatment, we believe Gleason 6 disease should not be labeled with this term. Our challenge now is to develop the technology to differentiate true Gleason 6 disease from the higher grades of dysplasia with which it can be associated. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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