Subcentimeter tumor lesion delineation for high-resolution 18F-FDG PET images: optimizing correction for partial-volume effects.
Unlabelled: In PET, partial-volume effects cause errors in estimation of size and activity for small objects with radiopharmaceutical uptake. Recent methods for image reconstruction, compared with traditional reconstruction techniques, include algorithms for resolution recovery that result in images...
| Publicado en: | Journal of Nuclear Medicine Technology Vol. 41; no. 2; pp. 85 - 92 |
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| Autores principales: | , , , , |
| Formato: | research Journal Article |
| Publicado: |
Society of Nuclear Medicine
Jun2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=107905046&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 107905046 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00914916 H7Q jtl: Journal of Nuclear Medicine Technology issn: 00914916 maglogo: N pubinfo: dt: Jun2013 vid: 41 iid: 2 pid: 2576 pub: Society of Nuclear Medicine place: Reston, Virginia artinfo: ui: 107905046 107905046 NLM23658206 2012140657 10.2967/jnmt.112.117234 NLM23658206 107905046 ppf: 85 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Subcentimeter tumor lesion delineation for high-resolution 18F-FDG PET images: optimizing correction for partial-volume effects. aug: au: Wallstén, Elin Axelsson, Jan Sundström, Torbjörn Riklund, Katrine Larsson, Anne affil: Department of Radiation Sciences, Umeå University, Umeå, Sweden. sug: subj: Fludeoxyglucose F 18 Diagnostic Use Head and Neck Neoplasms Pathology Head and Neck Neoplasms Radiography Image Processing, Computer Assisted Methods Tomography, Emission-Computed Methods Body Weights and Measures Human Phantoms, Imaging ab: Unlabelled: In PET, partial-volume effects cause errors in estimation of size and activity for small objects with radiopharmaceutical uptake. Recent methods for image reconstruction, compared with traditional reconstruction techniques, include algorithms for resolution recovery that result in images with higher resolution and enable quantification of size and activity of smaller objects. The purpose of this study was to evaluate a combination of 2 algorithms for volume delineation and partial-volume correction on uptake volumes smaller than 0.7 mL using image reconstruction algorithms with and without resolution recovery. Methods: Volumes of interests (VOIs) were delineated using a threshold intensity calculated as a weighted sum of tumor and background intensities. These VOIs were used for calculating correction factors by convolving a tumor mask with the system point-spread function. The methods algorithms were evaluated using a phantom constructed from 5 small different-sized balloons filled with (18)F-FDG in background activity. Six different backgrounds were used. Data were acquired using a PET/CT scanner, and the images were reconstructed using 2 iterative algorithms, one of which used a resolution recovery algorithm. Results: For the images reconstructed using the resolution recovery algorithm, the method for volume delineation resulted in VOI sizes that were correct within 1 SD for all balloons of a volume of 0.35 mL (equivalent diameter, 8.8 mm) and larger, in all backgrounds. For the images reconstructed without resolution recovery, the VOI sizes were background-dependent and generally less accurate. Correct volume delineations generally led to accurate activity estimates. Conclusion: The algorithms tested on the phantom developed for this study could, for this PET camera and these reconstruction algorithms, be used for accurate volume delineation and activity quantification of lesions 0.35 mL and larger. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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