What do autoinflammatory syndromes teach about common cutaneous diseases such as pyoderma gangrenosum? A commentary.
Pyoderma gangrenosum (PG) is a neutrophilic dermatosis characterized by ulcerating skin lesions with rapid onset and recalcitrant treatment course. PG treatment targets an array of inflammatory pathways with variable success. One of the hallmark features of PG is its association with a broad spectru...
| Publicado en: | Dermatologic Clinics Vol. 31; no. 3; pp. 427 - 436 |
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| Autores principales: | , |
| Formato: | Journal Article |
| Publicado: |
W B Saunders
2013 Jul
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=107907289&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 107907289 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07338635 DO3 jtl: Dermatologic Clinics issn: 07338635 maglogo: N pubinfo: dt: 2013 Jul vid: 31 iid: 3 pid: 1351 pub: W B Saunders place: Philadelphia, Pennsylvania artinfo: ui: 107907289 2012177746 10.1016/j.det.2013.04.004 NLM23827245 107907289 ppf: 427 ppct: 9 formats: tig: atl: What do autoinflammatory syndromes teach about common cutaneous diseases such as pyoderma gangrenosum? A commentary. aug: au: Butler, Daniel Shinkai, Kanade affil: University of Arizona School of Medicine, 1510 N Campbell Avenue, PO Box 245017, Tucson, AZ 85724, USA. sug: subj: Autoimmune Diseases Pathology Hereditary Autoinflammatory Diseases Pathology Pyoderma Gangrenosum Pathology Autoimmune Diseases Drug Therapy Diagnosis, Differential Hereditary Autoinflammatory Diseases Drug Therapy Immunosuppressive Agents Therapeutic Use Neutropenia Drug Therapy Neutropenia Pathology Pyoderma Gangrenosum Drug Therapy Syndrome ab: Pyoderma gangrenosum (PG) is a neutrophilic dermatosis characterized by ulcerating skin lesions with rapid onset and recalcitrant treatment course. PG treatment targets an array of inflammatory pathways with variable success. One of the hallmark features of PG is its association with a broad spectrum of systemic disorders. The authors hypothesize that there are common inflammatory pathways linking these systemic disorders to neutrophilic dermatoses. Rare autoinflammatory diseases offer insights into the understanding of inflammatory skin conditions. This article explores observations of the natural history of PG that illuminate aspects of PG pathogenesis, highlighting the role of autoinflammatory mediators. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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