Autoinflammatory diseases in pediatrics.

Autoinflammatory diseases (AIDs) are characterized by recurrent episodes of systemic and organ-specific inflammation. Many of these diseases share fever as a common presenting feature. Physicians need to consider AIDs in children with recurrent, unexplained fevers, when infectious and malignant caus...

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Publicado en:Dermatologic Clinics Vol. 31; no. 3; pp. 481 - 495
Autores principales: Hausmann, Jonathan S, Dedeoglu, Fatma
Formato: Journal Article
Publicado: W B Saunders 2013 Jul
Acceso en línea:Ver este registro en EBSCOhost
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        07338635
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      dt: 2013 Jul
      vid: 31
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      pub: W B Saunders
      place: Philadelphia, Pennsylvania
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        107907294
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        10.1016/j.det.2013.04.003
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        107907294
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        atl: Autoinflammatory diseases in pediatrics.
      aug:
        au:
          Hausmann, Jonathan S
          Dedeoglu, Fatma
        affil: Program in Rheumatology, Division of Immunology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA. Electronic address: jonathan.hausmann@childrens.harvard.edu.
      sug:
        subj:
          Autoimmune Diseases Complications
          Hereditary Autoinflammatory Diseases Complications
          Antiinflammatory Agents Therapeutic Use
          Analgesics, Nonnarcotic Therapeutic Use
          Autoimmune Diseases Diagnosis
          Autoimmune Diseases Drug Therapy
          Child
          Child, Preschool
          Diagnosis, Differential
          Fever Drug Therapy
          Fever Etiology
          Hereditary Autoinflammatory Diseases Diagnosis
          Hereditary Autoinflammatory Diseases Drug Therapy
          Infant
          Inflammation Drug Therapy
          Inflammation Etiology
          Syndrome
          Child: 6-12 years
          Child, Preschool: 2-5 years
          Infant: 1-23 months
      ab: Autoinflammatory diseases (AIDs) are characterized by recurrent episodes of systemic and organ-specific inflammation. Many of these diseases share fever as a common presenting feature. Physicians need to consider AIDs in children with recurrent, unexplained fevers, when infectious and malignant causes have been discarded. This article discusses the differential diagnosis of recurrent fever in children, with a focus on AIDs. It discusses pharyngitis, and cervical adenitis and the monogenic autoinflammatory diseases that cause recurrent fevers including familial Mediterranean fever, hyper-immunoglobulin (Ig) D and periodic fever syndrome, tumor necrosis factor receptor-associated periodic syndrome, cryopyrin associated periodic syndromes, deficiency of interleukin-36 receptor antagonist, Majeed syndrome, chronic atypical neutrophilic dermatosis with lipodystrophy and increased temperature syndrome, and deficiency of the interleukin-1 receptor antagonist. In addition, the granulomatous disorders, pyogenic sterile arthritis, pyoderma gangrenosum, and acne and Blau syndrome, will be discussed.
      pubtype: Academic Journal
      doctype: Journal Article
      ougenre: Article
    language: English
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