Thionamide-induced neutropenia and ecthyma in a pregnant patient with hyperthyroidism.
Background: Agranulocytosis is known to be a rare side effect of thionamides. This complication puts pregnant patients at particular risk for infections. Obstetricians caring for such patients have the difficult task of deciding between conservative or surgical management.Case: The patient is a 37-y...
| Publicado en: | Obstetrics & Gynecology Vol. 122; no. 2 part 2; pp. 490 - 493 |
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| Autores principales: | , , |
| Formato: | case study Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
Aug2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=107959160&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 107959160 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00297844 22Z jtl: Obstetrics & Gynecology issn: 00297844 maglogo: N pubinfo: dt: Aug2013 vid: 122 iid: 2 part 2 pid: 433 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 107959160 NLM23884271 2012200678 10.1097/AOG.0b013e3182864370 NLM23884271 107959160 ppf: 490 ppct: 3 formats: tig: atl: Thionamide-induced neutropenia and ecthyma in a pregnant patient with hyperthyroidism. aug: au: Thomas, Saly K Sheffield, Jeanne S Roberts, Scott W affil: University of Texas Southwestern Medical Center, Dallas, Texas. sug: subj: Thyroid Antagonists Adverse Effects Hyperthyroidism Drug Therapy Pregnancy Complications Drug Therapy Propylthiouracil Adverse Effects Adrenergic beta-Antagonists Therapeutic Use Adult Atenolol Therapeutic Use Dermatitis Medicamentosa Etiology Pyoderma Etiology Female Neutropenia Chemically Induced Neutropenia Complications Pregnancy Skin Diseases, Infectious Etiology Staphylococcus Aureus Adult: 19-44 years Female ab: Background: Agranulocytosis is known to be a rare side effect of thionamides. This complication puts pregnant patients at particular risk for infections. Obstetricians caring for such patients have the difficult task of deciding between conservative or surgical management.Case: The patient is a 37-year-old gravida 4 para 3 Hispanic woman at 11 weeks of gestation with recently diagnosed hyperthyroidism who presented with a neutropenic fever and ecthyma as a complication of thionamide use. She subsequently underwent a thyroidectomy and then had a spontaneous abortion on postoperative day 2.Conclusion: This patient had life-threatening thyrotoxicosis complicated by neutropenic fever and infection, likely caused by a reaction to thionamides. She quickly recovered with broad-spectrum antibiotics. She could not be restarted on methimazole or propylthiouracil as a result of agranulocytosis and thus underwent thyroidectomy. pubtype: Academic Journal doctype: case study Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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