A mechanically powered negative pressure device used in conjunction with a bioengineered cell-based product for the treatment of pyoderma gangrenosum: a case report.
Pyoderma gangrenosum (PG), an uncommon inflammatory and ulcerative skin disease, typically is treated medically with a combination of immunosuppression and local wound care, but evidence to guide care is limited. PG wounds can be difficult to heal. A 76-year-old male patient presented with a history...
| Published in: | Ostomy Wound Management Vol. 58; no. 9; pp. 44 - 49 |
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| Main Authors: | , , , , |
| Format: | case study pictorial tables/charts Journal Article |
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HMP Global
2012 Sep
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=107983838&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 107983838 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 08895899 4F3 jtl: Ostomy Wound Management issn: 08895899 maglogo: N pubinfo: dt: 2012 Sep vid: 58 iid: 9 pid: 20465 pub: HMP Global place: Malvern, Pennsylvania artinfo: ui: 107983838 107983838 2012010800 NLM22933700 107983838 ppf: 44 ppct: 5 formats: tig: atl: A mechanically powered negative pressure device used in conjunction with a bioengineered cell-based product for the treatment of pyoderma gangrenosum: a case report. aug: au: Neiderer, Katherine Martin, Billy Hoffman, Steven Jolley, David Dancho, James affil: Southern Arizona VA Health Care System and University of Arizona, Tucson, AZ 85723, USA. kateneiderer@hotmail.com sug: subj: Negative Pressure Wound Therapy Equipment and Supplies Pyoderma Gangrenosum Skin, Artificial Adrenal Cortex Hormones Aged Arthritis, Rheumatoid Male Treatment Outcomes Wound Healing Aged: 65+ years Male ab: Pyoderma gangrenosum (PG), an uncommon inflammatory and ulcerative skin disease, typically is treated medically with a combination of immunosuppression and local wound care, but evidence to guide care is limited. PG wounds can be difficult to heal. A 76-year-old male patient presented with a history of rheumatoid arthritis and recalcitrant PG. After 9 months of treatment with local wound care, steroids, and topical tacrolimus, the wound had increased in size from 1.8 cm x 1.5 cm to 7.2 cm x 5.6 cm. At that time, he was started on a regimen of five applications of a bioengineered cell- based product (one application every 2 weeks for a total of five applications) with twice-weekly mechanically powered negative pressure device changes. The latter was started at 75 mm Hg and changed to 125 mm Hg after 4 weeks. Oral corticosteroid therapy was initially started at 40 mg of prednisone, then slowly tapered to 20 mg, but could not be completely discontinued due to a flare in the patient's rheumatoid symptoms. The wound was completely healed after 16 weeks. Research to ascertain the effectiveness of protocols of PG care, including the combination treatment described, is needed to help clinicians provide evidence-based care for these challenging wounds. pubtype: Academic Journal doctype: case study pictorial tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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