Assessment of the Contribution of Electron Microscopy to Nanoparticle Characterization Sampled with Two Cascade Impactors.

This study assessed the contribution of electron microscopy to the characterization of nanoparticles and compared the degree of variability in sizes observed within each stage when sampled by two cascade impactors: an Electrical Low Pressure Impactor (ELPI) and a Micro-Orifice Uniform Deposit Impact...

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Publicado en:Journal of Occupational & Environmental Hygiene Vol. 10; no. 3; pp. 155 - 173
Autores principales: Noël, Alexandra, L'Espérance, Gilles, Cloutier, Yves, Plamondon, Philippe, Boucher, Julie, Philippe, Suzanne, Dion, Chantal, Truchon, Ginette, Zayed, Joseph
Formato: equations & formulas pictorial research tables/charts Journal Article
Publicado: Taylor & Francis Ltd Mar2013
Acceso en línea:Ver este registro en EBSCOhost
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        atl: Assessment of the Contribution of Electron Microscopy to Nanoparticle Characterization Sampled with Two Cascade Impactors.
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        au:
          Noël, Alexandra
          L'Espérance, Gilles
          Cloutier, Yves
          Plamondon, Philippe
          Boucher, Julie
          Philippe, Suzanne
          Dion, Chantal
          Truchon, Ginette
          Zayed, Joseph
        affil: Département de Santé environnementale et Santé au travail, Faculté de Médecine, Université de Montréal, Montréal, Québec, Canada
      sug:
        subj:
          Microscopy, Electron Utilization
          Nanoparticles Classification
          Air Pollutants, Occupational
          Aerosols
          Human
          Canada
          Particle Size
          Filtration
          Data Analysis Software
          Mann-Whitney U Test
          Funding Source
      ab: This study assessed the contribution of electron microscopy to the characterization of nanoparticles and compared the degree of variability in sizes observed within each stage when sampled by two cascade impactors: an Electrical Low Pressure Impactor (ELPI) and a Micro-Orifice Uniform Deposit Impactor (MOUDI). A TiO2 nanoparticle (5 nm) suspension was aerosolized in an inhalation chamber. Nanoparticles sampled by the impactors were collected on aluminum substrates or TEM carbon-coated copper grids using templates, specifically designed in our laboratories, for scanning and transmission electron microscopy (SEM, TEM) analysis, respectively. Nanoparticles were characterized using both SEM and TEM. Three different types of diameters (inner, outer, and circular) were measured by image analysis based on count and volume, for each impactor stage. Electron microscopy especially TEM, is well suited for the characterization of nanoparticles. The MOUDI, probably because of the rotation of its collection stages, which can minimize the resuspension of particles, gave more stable results and smaller geometric standard deviations per stage. Our data suggest that the best approach to estimate particle size by electron microscopy would rely on geometric means of measured circular diameters. Overall, the most reliable data were provided by the MO UDI and the TEM sampling technique on carbon-coated copper grids for this specific experiment. This study indicates interesting findings related to the assessment of impactors combined with electron microscopy for nanoparticle characterization. For future research, since cascade impactors are extensively used to characterize nano-aerosol exposure scenarios, high-performance field emission scanning electron microscopy (FESEM) should also be considered.
      pubtype: Academic Journal
      doctype:
        equations & formulas
        pictorial
        research
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        Journal Article
      ougenre: Article
    language: English
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