High Frequency Oscillatory Ventilation Versus Conventional Ventilation in a Newborn Piglet Model with Acute Lung Injury.
BACKGROUND: High frequency oscillatory ventilation (HFOV) is considered a protective strategy for human lungs. This study was designed to define microscopic structural features of lung injury following HFOV with a high lung volume strategy in newborn piglets with acute lung injury. METHODS: After ac...
| Publicado en: | Respiratory Care Vol. 58; no. 5; pp. 824 - 831 |
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| Autores principales: | , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Mary Ann Liebert, Inc.
May2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=108010623&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 108010623 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00201324 4GG jtl: Respiratory Care issn: 00201324 maglogo: N pubinfo: dt: May2013 vid: 58 iid: 5 pid: 1365 pub: Mary Ann Liebert, Inc. place: New Rochelle, New York artinfo: ui: 108010623 87386748 10.4187/respcare.01972 NLM23625895 108010623 ppf: 824 ppct: 7 formats: fmt: @attributes: type: P tig: atl: High Frequency Oscillatory Ventilation Versus Conventional Ventilation in a Newborn Piglet Model with Acute Lung Injury. aug: au: Wanhai Fu Xiaofei Qin Churning You Qiong Meng Youwei Zhao Yu Zhang affil: Department of Pediatrics, Guangdong Second Provincial People's Hospital, Guangzhou, China. sug: subj: Acute Lung Injury Therapy Respiration, Artificial Methods Respiration, Artificial Adverse Effects Ventilation, High Frequency Ventilator-Induced Lung Injury Physiopathology Acute Lung Injury Microbiology Animal Studies Swine Random Assignment Positive End-Expiratory Pressure Descriptive Statistics Blood Gas Analysis Airway Pressure Hemodynamics Data Analysis Software Analysis of Variance Post Hoc Analysis T-Tests ab: BACKGROUND: High frequency oscillatory ventilation (HFOV) is considered a protective strategy for human lungs. This study was designed to define microscopic structural features of lung injury following HFOV with a high lung volume strategy in newborn piglets with acute lung injury. METHODS: After acute lung injury with saline lavage, newborn piglets were randomly assigned to 5 study groups (6 in each group): control (no mechanical ventilation), conventional mechanical ventilation for 24 hours, conventional ventilation for 48 hours, HFOV for 24 hours, and HFOV for 48 hours. The right upper lung tissue was divided into the gravitation-dependent and gravitation- nondependent regions after the completion of mechanical ventilation. Under light microscopy, the numbers of polymorphonuclear leukocytes (PMNLs), alveolar macrophages, red blood cells, and hyaline membrane/alveolar edema were assessed in all lung tissues. Oxygenation index was continuously monitored. RESULTS: Our results showed that the degree of histopathologic lung damage in the gravitation-dependent region was greater than that in the gravitation-nondependent region. Compared with the control group, PMNLs, red blood cells and hyaline membrane/alveolar edemas were significantly increased and alveolar macrophages were significantly decreased in lung tissues of conventional ventilation and HFOV piglets. In HFOV with high lung volume strategy piglets, lung tissues had significantly fewer PMNLs, red blood cells, and hyaline membrane/alveolar edemas, and oxygenation was improved significantly, compared to those of the conventional ventilation piglets. CONCLUSIONS: Histopathologic lung damage in newborn piglets with lung injury was more severe in the gravitation-dependent region than in the gravitation-nondependent region. HFOV with high lung volume strategy reduced pulmonary PMNL infiltration, hemorrhage, alveolar edema, and hyaline membrane formation with improved oxygenation. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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