Feasibility Study of Automated Overnight Closed-Loop Glucose Control Under MD-Logic Artificial Pancreas in Patients with Type 1 Diabetes: The DREAM Project.
Abstract Background: Artificial pancreas systems may offer a potential major impact on the normalization of metabolic control and preventing hypoglycemic events. This study aims to establish near-normal overnight glucose control and reduce the risk of nocturnal hypoglycemia using the MD-Logic Artifi...
| Publicado en: | Diabetes Technology & Therapeutics Vol. 14; no. 8; pp. 728 - 736 |
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| Autores principales: | , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Mary Ann Liebert, Inc.
2012 Aug
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=108066625&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 108066625 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15209156 N3C jtl: Diabetes Technology & Therapeutics issn: 15209156 maglogo: N pubinfo: dt: 2012 Aug vid: 14 iid: 8 pid: 1365 pub: Mary Ann Liebert, Inc. place: New Rochelle, New York artinfo: ui: 108066625 108066625 2011634994 10.1089/dia.2012.0004 NLM22853723 108066625 ppf: 728 ppct: 8 formats: tig: atl: Feasibility Study of Automated Overnight Closed-Loop Glucose Control Under MD-Logic Artificial Pancreas in Patients with Type 1 Diabetes: The DREAM Project. aug: au: Nimri R Atlas E Ajzensztejn M Miller S Oron T Phillip M affil: 1 The Jesse Z. and Sara Lea Shafer Institute for Endocrinology and Diabetes, The National Center for Childhood Diabetes, Schneider Children's Medical Center of Israel , Petah Tikva, Israel . sug: subj: Algorithms Blood Glucose Metabolism Diabetes Mellitus, Type 1 Blood Glycated Hemoglobin Metabolism Hypoglycemic Agents Administration and Dosage Insulin Administration and Dosage Artificial Organs Blood Glucose Self-Monitoring Circadian Rhythm Diabetes Mellitus, Type 1 Drug Therapy Equipment Design Pilot Studies Female Human Insulin Infusion Systems Male Monitoring, Physiologic Young Adult Female Male ab: Abstract Background: Artificial pancreas systems may offer a potential major impact on the normalization of metabolic control and preventing hypoglycemic events. This study aims to establish near-normal overnight glucose control and reduce the risk of nocturnal hypoglycemia using the MD-Logic Artificial Pancreas (MDLAP), an algorithm that was developed by our research group. This inpatient feasibility study is the first step towards implementing an overnight closed-loop MDLAP system at the patient's home. Subjects and Methods: Seven patients with type 1 diabetes (three adolescents and four adults; mean±SD age, 20.6±4.7 years; duration of diabetes, 9.6±2.6 years; body mass index, 24.3±3.9 kg/m(2); and glycated hemoglobin, 7.8±0.8%) participated in a total of 14 closed-loop overnight sessions. Each participant underwent two closed-loop inpatient sessions starting at dinner alone and at dinner following exercise. The closed-loop inpatient sessions were compared with data derived from nights spent at home with an open-loop system in a similar scenario to the study protocol. Results: The mean percentage of time spent in the near normal glucose range of 63-140 mg/dL was 83±16%, and the median (interquartile range) was 85% (78-92%) for the overnight closed-loop sessions compared with 34±31% and 27% (6-57%) in the homecare open-loop setting, respectively. During the overnight closed-loop sessions at dinner alone 92±9% of the sensor values ranged within target range, compared with 73±19% for the sessions following exercise (P=0.03). No hypoglycemic (<63 mg/dL) events occurred during the closed-loop sessions. Conclusion: Closed-loop insulin delivery under MDLAP is a feasible and safe solution to control overnight glycemia. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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