Age-Related Impairment of Visual Recognition Memory Correlates with Impaired Synaptic Distribution of GluA2 and Protein Kinase M in the Dentate Gyrus.
Abstract Age-related functional alterations in the perforant path projection from the entorhinal cortex to the dentate gyrus (DG) of the hippocampus play a major role in age-related memory impairments, but little is known about the molecular mechanisms responsible for these changes. In a recent stud...
| Publicado en: | Rejuvenation Research Vol. 15; no. 5; pp. 530 - 534 |
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| Autor principal: | |
| Formato: | Journal Article |
| Publicado: |
Mary Ann Liebert, Inc.
2012 Oct
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=108073855&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 108073855 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15491684 1E3T jtl: Rejuvenation Research issn: 15491684 maglogo: N pubinfo: dt: 2012 Oct vid: 15 iid: 5 pid: 1365 pub: Mary Ann Liebert, Inc. place: New Rochelle, New York artinfo: ui: 108073855 2011726114 10.1089/rej.2012.1375 NLM22985047 108073855 ppf: 530 ppct: 4 formats: tig: atl: Age-Related Impairment of Visual Recognition Memory Correlates with Impaired Synaptic Distribution of GluA2 and Protein Kinase M in the Dentate Gyrus. aug: au: Aicardi G affil: Department of Human and General Physiology, and Interdepartmental Centre ''Luigi Galvani'' for the Study of Biophysics, Bioinformatics and Biocomplexity. University of Bologna , Bologna, Italy . sug: subj: Aging Physiology Hippocampus Metabolism Memory Nervous System Metabolism Receptors, Cell Surface Metabolism Recognition (Psychology) Visual Perception Aging Psychosocial Factors ab: Abstract Age-related functional alterations in the perforant path projection from the entorhinal cortex to the dentate gyrus (DG) of the hippocampus play a major role in age-related memory impairments, but little is known about the molecular mechanisms responsible for these changes. In a recent study, young and aged monkeys were tested on the visual recognition memory test 'delayed nonmatching-to-sample'; then, electron microscopic immunocytochemistry was performed in the hippocampal DG to determine the subcellular localization of the GluA2 subunit of the glutamate [alpha]-amino-3-hydroxy-5-methyl-4- isoxazole-propionic acid receptor (AMPAR) and protein kinase M (PKM), which promotes memory storage by regulating GluA2-containing AMPAR trafficking. The results obtained suggest that age-related deficits in visual recognition memory are coupled with impairment in PKM-dependent maintenance of GluA2 at the synapse. Together with previous evidences of the critical role of PKM in memory consolidation, these data render this enzyme an attractive potential therapeutic target for treating age-related memory decline, and support the view that the pharmacological manipulation of AMPAR trafficking in the synapses may provide new insights in the search of memory enhancers for aged individuals, including those affected by Alzheimer disease. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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