Evidence-based guideline update: Steroids and antivirals for Bell palsy: Report of the Guideline Development Subcommittee of the American Academy of Neurology.
OBJECTIVE: To review evidence published since the 2001 American Academy of Neurology (AAN) practice parameter regarding the effectiveness, safety, and tolerability of steroids and antiviral agents for Bell palsy. METHODS: We searched Medline and the Cochrane Database of Controlled Clinical Trials fo...
| Publicado en: | Neurology Vol. 79; no. 22; pp. 2209 - 2214 |
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| Autores principales: | , |
| Formato: | research systematic review Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
11/27/2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=108079119&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 108079119 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283878 NRO jtl: Neurology issn: 00283878 maglogo: N pubinfo: dt: 11/27/2012 vid: 79 iid: 22 pid: 433 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 108079119 108079119 2011773174 10.1212/WNL.0b013e318275978c NLM23136264 108079119 ppf: 2209 ppct: 5 formats: tig: atl: Evidence-based guideline update: Steroids and antivirals for Bell palsy: Report of the Guideline Development Subcommittee of the American Academy of Neurology. aug: au: Gronseth GS Paduga R affil: From the Department of Neurology, University of Kansas Medical Center, Kansas City. sug: subj: Antiviral Agents Therapeutic Use Bell Palsy Drug Therapy Medical Practice, Evidence-Based Standards Neurology Standards Practice Guidelines Standards Steroids Therapeutic Use Cochrane Library Human Medline Systematic Review United States ab: OBJECTIVE: To review evidence published since the 2001 American Academy of Neurology (AAN) practice parameter regarding the effectiveness, safety, and tolerability of steroids and antiviral agents for Bell palsy. METHODS: We searched Medline and the Cochrane Database of Controlled Clinical Trials for studies published since January 2000 that compared facial functional outcomes in patients with Bell palsy receiving steroids/antivirals with patients not receiving these medications. We graded each study (Class I-IV) using the AAN therapeutic classification of evidence scheme. We compared the proportion of patients recovering facial function in the treated group with the proportion of patients recovering facial function in the control group. RESULTS: Nine studies published since June 2000 on patients with Bell palsy receiving steroids/antiviral agents were identified. Two of these studies were rated Class I because of high methodologic quality. CONCLUSIONS AND RECOMMENDATIONS: For patients with new-onset Bell palsy, steroids are highly likely to be effective and should be offered to increase the probability of recovery of facial nerve function (2 Class I studies, Level A) (risk difference 12.8%-15%). For patients with new-onset Bell palsy, antiviral agents in combination with steroids do not increase the probability of facial functional recovery by >7%. Because of the possibility of a modest increase in recovery, patients might be offered antivirals (in addition to steroids) (Level C). Patients offered antivirals should be counseled that a benefit from antivirals has not been established, and, if there is a benefit, it is likely that it is modest at best. pubtype: Academic Journal doctype: research systematic review Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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