Pyoderma Gangrenosum, Acne Conglobata, Suppurative Hidradenitis, and Axial Spondyloarthritis: Efficacy of Anti-Tumor Necrosis Factor [alpha] Therapy.

ABSTRACT: We report the case of a patient with a simultaneous presence of pyoderma gangrenosum, acne conglobata, suppurative hidradenitis, and axial spondyloarthritis. This condition differs from both the PASH (pyoderma gangrenosum, acne, and suppurative hidradenitis) syndrome, in which arthritis is...

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Publicado en:JRC: Journal of Clinical Rheumatology Vol. 18; no. 8; pp. 413 - 416
Autor principal: Bruzzese V
Formato: case study Journal Article
Publicado: Lippincott Williams & Wilkins 2012 Dec
Acceso en línea:Ver este registro en EBSCOhost
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      dt: 2012 Dec
      vid: 18
      iid: 8
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      pub: Lippincott Williams & Wilkins
      place: Baltimore, Maryland
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        atl: Pyoderma Gangrenosum, Acne Conglobata, Suppurative Hidradenitis, and Axial Spondyloarthritis: Efficacy of Anti-Tumor Necrosis Factor [alpha] Therapy.
      aug:
        au: Bruzzese V
        affil: From the Internal Medicine and Rheumatology Unit, 'Nuovo Regina Margherita' Hospital, Rome, Italy.
      sug:
        subj:
          Acne Vulgaris Drug Therapy
          Antiinflammatory Agents, Non-Steroidal Therapeutic Use
          Antibodies, Monoclonal Therapeutic Use
          Hidradenitis Suppurativa Drug Therapy
          Pyoderma Gangrenosum Drug Therapy
          Spondylarthritis Drug Therapy
          Acne Vulgaris Complications
          Adult
          Blood Sedimentation
          C-Reactive Protein Analysis
          Hidradenitis Suppurativa Complications
          Infusions, Intravenous
          Isoniazid Therapeutic Use
          Male
          Pyoderma Gangrenosum Complications
          Spondylarthritis Complications
          Tumor Necrosis Factor Antagonists and Inhibitors
          Adult: 19-44 years
          Male
      ab: ABSTRACT: We report the case of a patient with a simultaneous presence of pyoderma gangrenosum, acne conglobata, suppurative hidradenitis, and axial spondyloarthritis. This condition differs from both the PASH (pyoderma gangrenosum, acne, and suppurative hidradenitis) syndrome, in which arthritis is absent, and the PAPA (pyogenic arthritis, pyoderma gangrenosum, and acne) syndrome, in which suppurative hidradenitis is lacking. Our patient failed to respond to etanercept therapy, whereas all dermatologic and rheumatic manifestations completely regressed following infliximab infusion. We therefore propose that simultaneous presence of pyoderma gangrenosum, acne conglobata, suppurative hidradenitis, and seronegative spondyloarthritis might represent a distinct syndrome that could be termed the PASS syndrome. Tumor necrosis factor [alpha] therapies seem to play selective roles.
      pubtype: Academic Journal
      doctype:
        case study
        Journal Article
      ougenre: Article
    language: English
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