The trend in newly diagnosed Crohn's disease and extraintestinal manifestations of Crohn's disease in central China: a retrospective study of a single center.
BACKGROUND AND AIMS: The incidence of Crohn's disease (CD) is increasing and has already become a refractory disorder in China. Data on extraintestinal manifestations (EIMs) in CD are rare, especially in Asians. We aimed to evaluate the trend of newly diagnosed CD and the prevalence and risk factors...
| Publicado en: | European Journal of Gastroenterology & Hepatology Vol. 24; no. 12; pp. 1424 - 1430 |
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| Autores principales: | , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
2012 Dec
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=108111557&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 108111557 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0954691X 8CE jtl: European Journal of Gastroenterology & Hepatology issn: 0954691X maglogo: N pubinfo: dt: 2012 Dec vid: 24 iid: 12 pid: 5086 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 108111557 108111557 2011760052 10.1097/MEG.0b013e3283583e5c NLM22895389 108111557 ppf: 1424 ppct: 6 formats: tig: atl: The trend in newly diagnosed Crohn's disease and extraintestinal manifestations of Crohn's disease in central China: a retrospective study of a single center. aug: au: Yi, Fengming Chen, Min Huang, Meifang Li, Jin Zhao, Junzhang Li, Lixia Xia, Bing affil: aDepartment of Gastroenterology, Zhongnan Hospital, Wuhan University School of Medicine bThe Hubei Clinical Center & Key Laboratory of Intestinal & Colorectal Diseases, Wuhan, People's Republic of China. sug: subj: Crohn Disease Complications Crohn Disease Diagnosis Risk Assessment Academic Medical Centers Adult Chi Square Test China Data Analysis Software Descriptive Statistics Female Funding Source Human Logistic Regression Male Middle Age Multivariate Analysis Registries, Disease Retrospective Design T-Tests Yates' Continuity Correction Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: BACKGROUND AND AIMS: The incidence of Crohn's disease (CD) is increasing and has already become a refractory disorder in China. Data on extraintestinal manifestations (EIMs) in CD are rare, especially in Asians. We aimed to evaluate the trend of newly diagnosed CD and the prevalence and risk factors of EIMs in a clinical center in central China. MATERIALS AND METHODS: A total of 153 patients with CD were selected from the center from 1986 to 2011. Demographic and clinical data were collected from the center. The prevalence and risk factors of EIMs were retrospectively analyzed. RESULTS: The cases of CD increased from one in 1986 to 24 in 2011. It seemed to have two peaks for age at diagnosis: 21-25 and 36-40 years. Among these patients, 20 (13.07%) had one to three EIMs. The following EIMs were diagnosed: arthritis (4.58%), pyoderma gangrenosum (0.65%), erythema nodosum (1.31%), aphthous stomatitis (7.84%), ankylosing spondylitis (0.65%), and psoriasis (0.65%). In univariate analysis, patients with EIMs seemed to have shorter disease duration at diagnosis (P<0.001); those treated with intravenous injection of corticosteroids, immunosuppressants, and infliximab before or recently were the most susceptible to EIMs (P=0.012, 0.005, and 0.026, respectively). Multivariate analysis was performed by logistic regression to identify the risk factors of EIMs subsequently; however, no risk factors were identified (P>0.005). CONCLUSION: The incidence of CD was increasing remarkably at our center, and the age distributions were concentrated in the 21-25- and 36-40-year age groups. EIMs seemed to be rare in our Chinese patients with CD, and no risk factors correlated with EIMs, which was quite different from Western countries. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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