Assessment of cognitive function while on low-dose propranolol: implications for usage by survivors in a disabled submarine.
While awaiting rescue from a disabled submarine (DISSUB), survivors will likely endure an atmosphere of rising CO2 which will eventually be lethal. Previously, it was determined that low-dose propranolol reduces resting metabolic carbon dioxide production and therefore may increase survival time in...
| Publicado en: | Military Medicine Vol. 177; no. 4; pp. 451 - 456 |
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| Autores principales: | , , , , , |
| Formato: | research randomized controlled trial Journal Article |
| Publicado: |
Oxford University Press / USA
Apr2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=108114476&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 108114476 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00264075 4DV jtl: Military Medicine issn: 00264075 maglogo: N pubinfo: dt: Apr2012 vid: 177 iid: 4 pid: 622 pub: Oxford University Press / USA artinfo: ui: 108114476 108114476 NLM22594137 2011555606 10.7205/milmed-d-11-00309 NLM22594137 108114476 ppf: 451 ppct: 5 formats: fmt: @attributes: type: P tig: atl: Assessment of cognitive function while on low-dose propranolol: implications for usage by survivors in a disabled submarine. aug: au: Reini SA Fothergill DM Horn WG Reini, Seth A Fothergill, David M Horn, Wayne G affil: Naval Submarine Medical Research Laboratory, Building 156 Trout Avenue, Naval Submarine Base New London, Box 900, Groton, CT 06349-5900, USA sug: subj: Adrenergic beta-Antagonists Therapeutic Use Carbon Dioxide Metabolism Cognition Drug Effects Medicine Military Medicine Propranolol Therapeutic Use Survivors Adult Algorithms Crossover Design Dose-Response Relationship, Drug Double-Blind Studies Human Male Military Personnel Neuropsychological Tests Randomized Controlled Trials Risk Assessment Adult: 19-44 years Male ab: While awaiting rescue from a disabled submarine (DISSUB), survivors will likely endure an atmosphere of rising CO2 which will eventually be lethal. Previously, it was determined that low-dose propranolol reduces resting metabolic carbon dioxide production and therefore may increase survival time in this scenario. The actions and decisions survivors would carry out in a DISSUB situation would require an unaltered cognition state. Therefore, we wanted to determine if low-dose propranolol impairs cognitive function. Eight healthy males completed a counterbalanced, randomized, placebo-controlled, double-blinded crossover study in which each subject received propranolol (40 mg twice daily) or placebo (lactose pill twice daily) over a 72-hour period. The alternate condition was separated by a minimum 96-hour washout period. Subjects performed a series of 6 tasks from the Automated Neuropsychological Assessment Metrics (ANAM) battery and answered a self-report sleepiness scale each morning and afternoon. Subjects exhibited increased accuracy in one of the ANAM tasks while on propranolol compared to placebo, but showed no difference between treatments on the other 5 tasks and sleepiness scale. These results suggest that 40 mg of propranolol taken twice daily does not significantly impair cognitive function and may be a viable option for use in a DISSUB scenario. pubtype: Academic Journal doctype: research randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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