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Multicenter validation of a bedside antisaccade task as a measure of executive function.

Objective: To create and validate a simple, standardized version of the antisaccade (AS) task that requires no specialized equipment for use as a measure of executive function in multicenter clinical studies.Methods: The bedside AS (BAS) task consisted of 40 pseudorandomized AS trials presented on a...

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Published in:Neurology Vol. 78; no. 23; pp. 1824 - 1832
Main Authors: Hellmuth J, Mirsky J, Heuer HW, Matlin A, Jafari A, Garbutt S, Widmeyer M, Berhel A, Sinha L, Miller BL, Kramer JH, Boxer AL, Hellmuth, J, Mirsky, J, Heuer, H W, Matlin, A, Jafari, A, Garbutt, S, Widmeyer, M, Berhel, A
Format: research Journal Article
Published: Lippincott Williams & Wilkins 6/5/2012
Online Access:View this record in EBSCOhost
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      dt: 6/5/2012
      vid: 78
      iid: 23
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      pub: Lippincott Williams & Wilkins
      place: Baltimore, Maryland
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        108121137
        108121137
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        2011577447
        10.1212/WNL.0b013e318258f785
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        108121137
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        atl: Multicenter validation of a bedside antisaccade task as a measure of executive function.
      aug:
        au:
          Hellmuth J
          Mirsky J
          Heuer HW
          Matlin A
          Jafari A
          Garbutt S
          Widmeyer M
          Berhel A
          Sinha L
          Miller BL
          Kramer JH
          Boxer AL
          Hellmuth, J
          Mirsky, J
          Heuer, H W
          Matlin, A
          Jafari, A
          Garbutt, S
          Widmeyer, M
          Berhel, A
        affil: Department of Neurology, Memory and Aging Center, University of California, San Francisco, USA
      sug:
        subj:
          Brain Diseases Physiopathology
          Eye Movements Physiology
          Mental Processes
          Neuropsychological Tests Standards
          Aged
          Aging Physiology
          Cognition Disorders Physiopathology
          Dementia Physiopathology
          Eye Movement Measurements
          Female
          Human
          Male
          Middle Age
          Prospective Studies
          Aged: 65+ years
          Middle Aged: 45-64 years
          Female
          Male
      ab: Objective: To create and validate a simple, standardized version of the antisaccade (AS) task that requires no specialized equipment for use as a measure of executive function in multicenter clinical studies.Methods: The bedside AS (BAS) task consisted of 40 pseudorandomized AS trials presented on a laptop computer. BAS performance was compared with AS performance measured using an infrared eye tracker in normal elders (NE) and individuals with mild cognitive impairment (MCI) or dementia (n = 33). The neuropsychological domain specificity of the BAS was then determined in a cohort of NE, MCI, and dementia (n = 103) at UCSF, and the BAS was validated as a measure of executive function in a 6-center cohort (n = 397) of normal adults and patients with a variety of brain diseases.Results: Performance on the BAS and laboratory AS task was strongly correlated and BAS performance was most strongly associated with neuropsychological measures of executive function. Even after controlling for disease severity and processing speed, BAS performance was associated with multiple assessments of executive function, most strongly the informant-based Frontal Systems Behavior Scale.Conclusions: The BAS is a simple, valid measure of executive function in aging and neurologic disease.
      pubtype: Academic Journal
      doctype:
        research
        Journal Article
      ougenre: Article
    language: English
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