Adverse Drug Reactions in Older People: Detection and Prevention.

Adverse drug reactions (ADRs) in older adults are an important healthcare problem since they are frequently a cause of hospitalization, occur commonly during admission, and are an important cause of morbidity and mortality. Older adults are particularly susceptible to ADRs because they are usually o...

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Publicado en:Drugs & Aging Vol. 29; no. 6; pp. 453 - 463
Autores principales: Petrovic, Mirko, Van der Cammen, Tischa, Onder, Graziano
Formato: review tables/charts Journal Article
Publicado: Springer Nature 2012
Acceso en línea:Ver este registro en EBSCOhost
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        atl: Adverse Drug Reactions in Older People: Detection and Prevention.
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          Petrovic, Mirko
          Van der Cammen, Tischa
          Onder, Graziano
        affil: Department of Geriatrics, Ghent University Hospital, Belgium
      sug:
        subj:
          Adverse Drug Event Evaluation
          Adverse Drug Event Prevention and Control
          Aged
          Aged: 65+ years
      ab: Adverse drug reactions (ADRs) in older adults are an important healthcare problem since they are frequently a cause of hospitalization, occur commonly during admission, and are an important cause of morbidity and mortality. Older adults are particularly susceptible to ADRs because they are usually on multiple drug regimens and because age is associated with changes in pharmacokinetics and pharmacodynamics. The presentation of an ADR in older adults is often atypical, which further complicates its recognition. One potential strategy for improving recognition of ADRs is to identify those patients who are at risk of an ADR. The recently developed GerontoNet ADR Risk Score is a practical tool for identification of older patients who are at increased risk for an ADR and who may represent a target for interventions aimed at reducing ADRs. Provision of adequate education in the domain of clinical geriatric pharmacology can improve recognition of ADRs. Besides formal surveillance systems, built-in computer programs with electronic prescribing databases and clinical pharmacist involvement in patient care within multidisciplinary geriatric teams might help to minimize the occurrence of ADRs. In addition, a number of actions can be taken in hospitals to stimulate appropriate prescribing and to assure adequate communication between primary and hospital care. In older adults with complex medical problems and needs, a global evaluation obtained through a comprehensive geriatric assessment may be helpful in simplifying drug prescription and prioritizing pharmacological and healthcare needs, resulting in an improvement in quality of prescribing.
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    language: English
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