Risk factors associated with relapse in Japanese patients with microscopic polyangiitis.
OBJECTIVE: We retrospectively studied the risk factors associated with relapse during remission maintenance therapy for myeloperoxidase-antineutrophil cytoplasmic autoantibody (MPO-ANCA)-positive microscopic polyangiitis (MPA). METHODS: Sixty-two patients diagnosed with MPA according to the European...
| Publicado en: | Journal of Rheumatology Vol. 39; no. 3; pp. 545 - 552 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Journal of Rheumatology Publishing Co. Ltd.
Mar2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=108170476&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 108170476 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0315162X 4CM jtl: Journal of Rheumatology issn: 0315162X maglogo: N pubinfo: dt: Mar2012 vid: 39 iid: 3 pid: 6803 pub: Journal of Rheumatology Publishing Co. Ltd. place: Toronto, Ontario artinfo: ui: 108170476 2011494808 10.3899/jrheum.110705 NLM22174198 108170476 ppf: 545 ppct: 7 formats: tig: atl: Risk factors associated with relapse in Japanese patients with microscopic polyangiitis. aug: au: Wada, Takashi Hara, Akinori Arimura, Yoshihiro Sada, Ken-Ei Makino, Hirofumi affil: Division of Nephrology, Department of Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-8641, Japan. twada@m-kanazawa.jp. sug: subj: Recurrence Risk Factors Vasculitis Epidemiology Aged Clinical Assessment Tools Confidence Intervals Cox Proportional Hazards Model Data Analysis Software Data Analysis, Statistical Descriptive Statistics Female Funding Source Human Japan Kaplan-Meier Estimator Kruskal-Wallis Test Male Nonexperimental Studies Odds Ratio P-Value Regression Retrospective Design Vasculitis Drug Therapy Vasculitis Prognosis Aged: 65+ years Female Male ab: OBJECTIVE: We retrospectively studied the risk factors associated with relapse during remission maintenance therapy for myeloperoxidase-antineutrophil cytoplasmic autoantibody (MPO-ANCA)-positive microscopic polyangiitis (MPA). METHODS: Sixty-two patients diagnosed with MPA according to the European Medicines Agency classification algorithm during a 2-year period from January 1, 2005, to December 31, 2006, and who achieved remission after the first remission-induction therapy, were examined (registration no. UMIN000001785). RESULTS: The patient group comprised 25 men and 37 women aged 70.0 ± 8.9 years. The mean observation period was 30.2 ± 15.9 months. The rate of relapse was 24.2% (15/62), and mean interval between remission and relapse was 16.9 ± 13.5 months. During maintenance therapy following remission, the risk of relapse increased when the reduction rate of prednisolone increased above 0.8 mg/month (OR 12.6, 95% CI 2.2-97.9). Proteinuria at the start of maintenance therapy (regression coefficient 1.991 ± 0.758, p < 0.05) and the change in red blood cell counts in urine during the period from the start of maintenance therapy to the final observation (regression coefficient 0.126 ± 0.040, p < 0.01) were identified as risk factors influencing the vasculitis damage index. CONCLUSION: In Japan, relapse of MPO-ANCA-positive MPA may be associated with the reduction rate of oral prednisolone administration during maintenance therapy. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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