Physiologic dysfunction scores and cognitive function test performance in U.S. adults.
Objective: To investigate the relationship between a measure of cumulative physiologic dysfunction and specific domains of cognitive function.Methods: We examined a summary score measuring physiologic dysfunction, a multisystem measure of the body's ability to effectively adapt to physical and psych...
| Publicado en: | Psychosomatic Medicine Vol. 74; no. 1; pp. 81 - 89 |
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| Autores principales: | , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
2012 Jan
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=108218824&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 108218824 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00333174 2C8 jtl: Psychosomatic Medicine issn: 00333174 maglogo: N pubinfo: dt: 2012 Jan vid: 74 iid: 1 pid: 433 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 108218824 108218824 NLM22155941 2011423925 10.1097/PSY.0b013e3182385b1e NLM22155941 PMC3708451 108218824 ppf: 81 ppct: 8 formats: tig: atl: Physiologic dysfunction scores and cognitive function test performance in U.S. adults. aug: au: Kobrosly RW Seplaki CL Jones CM van Wijngaarden E Kobrosly, Roni W Seplaki, Christopher L Jones, Courtney M van Wijngaarden, Edwin affil: MPH, Department of Community and Preventive Medicine, School of Medicine and Dentistry, University of Rochester Medical Center, 601 Elmwood Ave, Box 644, Rochester, NY 14642, USA sug: subj: Cognition Cognition Disorders Epidemiology Health Status Memory, Short Term Neuropsychological Tests Statistics and Numerical Data Adaptation, Physiological Physiology Adaptation, Psychological Adolescence Adult Aged Aged, 80 and Over Biological Markers Child Child, Preschool Cross Sectional Studies Endocrine Glands Physiology Female Human Hypothalamus Physiology Infant Male Middle Age Models, Biological Psychomotor Performance Reaction Time Regression Socioeconomic Factors Surveys United States Young Adult Adolescent: 13-18 years Adult: 19-44 years Aged: 65+ years Aged, 80 & over Child: 6-12 years Child, Preschool: 2-5 years Infant: 1-23 months Middle Aged: 45-64 years Female Male ab: Objective: To investigate the relationship between a measure of cumulative physiologic dysfunction and specific domains of cognitive function.Methods: We examined a summary score measuring physiologic dysfunction, a multisystem measure of the body's ability to effectively adapt to physical and psychological demands, in relation to cognitive function deficits in a population of 4511 adults aged 20 to 59 who participated in the Third National Health and Nutrition Examination Survey (1988-1994). Measures of cognitive function comprised three domains: working memory, visuomotor speed, and perceptual-motor speed. "Physiologic dysfunction" scores summarizing measures of cardiovascular, immunologic, kidney, and liver functions were explored. We used multiple linear regression models to estimate associations between cognitive function measures and physiologic dysfunction scores, adjusting for socioeconomic factors, test conditions, and self-reported health factors.Results: We noted a dose-response relationship between physiologic dysfunction and working memory (coefficient = 0.207, 95% confidence interval = 0.066-0.348, p < .0001), which persisted after adjustment for all covariates (p = .03). We did not observe any significant relationships between dysfunction scores and visuomotor (p = .37) or perceptual-motor ability (p = .33).Conclusions: Our findings suggest that multisystem physiologic dysfunction is associated with working memory. Future longitudinal studies are needed to clarify the underlying mechanisms and explore the persistency of this association into later life. We suggest that such studies should incorporate physiologic data, neuroendocrine parameters, and a wide range of specific cognitive domains. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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