The favourable effect of Helicobacter pylori eradication therapy in patients with recurrent angina-like chest pain and non-responsive to proton pump inhibitors - a preliminary study.
Introduction: The outcome of Helicobacter pylori (Hp) eradication therapy from the aspect of prevention of chest pain recurrence is still uncertain. The aim of this study was to assess the influence of Hp eradication therapy on the risk of hospitalization due to acute coronary syndrome.Material and...
| Publicado en: | Archives of Medical Science Vol. 7; no. 1; pp. 73 - 81 |
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| Autores principales: | , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Termedia Publishing House
2011 Feb
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=108224303&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 108224303 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 17341922 77TB jtl: Archives of Medical Science issn: 17341922 maglogo: N pubinfo: dt: 2011 Feb vid: 7 iid: 1 pid: 24295 pub: Termedia Publishing House place: , <Blank> artinfo: ui: 108224303 108224303 NLM22291736 2011342690 10.5114/aoms.2011.20607 NLM22291736 PMC3258683 108224303 ppf: 73 ppct: 8 formats: tig: atl: The favourable effect of Helicobacter pylori eradication therapy in patients with recurrent angina-like chest pain and non-responsive to proton pump inhibitors - a preliminary study. aug: au: Budzynski, Jacek Budzyński, Jacek affil: Department of Gastroenterology, Vascular Diseases and Internal Medicine, Nicolaus Copernicus University in Torun, Ludwik Rydygier Collegium Medicum, Bydgoszcz, Poland sug: subj: Angina Pectoris Coronary Disease Prevention and Control Gastroesophageal Reflux Prevention and Control Helicobacter Infections Therapy Metabolic Syndrome X Prevention and Control Adult Angiography Biopsy Chi Square Test Cox Proportional Hazards Model Data Analysis Software Descriptive Statistics Drug Resistance Electrocardiography Equipment and Supplies Female Fisher's Exact Test Funding Source Human Kaplan-Meier Estimator Male Middle Age Multivariate Analysis Poland Proton Pump Inhibitors Sex Factors T-Tests Wilcoxon Rank Sum Test Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: Introduction: The outcome of Helicobacter pylori (Hp) eradication therapy from the aspect of prevention of chest pain recurrence is still uncertain. The aim of this study was to assess the influence of Hp eradication therapy on the risk of hospitalization due to acute coronary syndrome.Material and Methods: The analysis was carried out in 63 consecutive patients with recurrent retrosternal symptoms: 28 (44%) with significant coronary artery narrowing in coronarography not qualified for revascularization by an invasive cardiologist, and 35 (56%) with no obstructive coronary artery lesions. In 33 (52%) of the patients, Hp infection was found and standard eradication therapy with omeprazole (2 × 20 mg), amoxicillin (2 × 1 g) and metronidazole (2 × 500 mg) was recommended. The mean follow-up period was 977 ±249 days.Results: Chest pain requiring hospitalization because of unstable angina within the follow-up period was observed in 9 (27%) of the Hp-infected individuals and in 15 (50%) subjects in whom a urease test and histology did not confirm this infection (p = 0.055). The recommendation of Hp-eradication treatment was a significant factor prolonging the hospitalization-free period, both in the two Kaplan-Meier curve analyses (Cox's F test = 1.96; p = 0.049) and the Cox proportional hazard model (beta = -1.18; p = 0.045), but was weaker than the effect of the non-obstructive coronary angiogram (beta = -1.45; p = 0.03).Conclusions: The recommendation of Hp-eradication therapy may prolong the hospitalization-free period for patients with recurrent chest pain. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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