Inverse correlation between allergy markers and Helicobacter pylori infection in children is associated with elevated levels of TGF-[beta].
OBJECTIVES: We evaluated allergy/hypersensitivity clinical markers and their correlation with Helicobactor pylori infection in children and adults to analyze how early acquisition of H. pylori could modulate allergic disorder expression. PATIENTS AND METHODS: H. pylori presence was assessed by the r...
| Publicado en: | European Journal of Gastroenterology & Hepatology Vol. 23; no. 8; pp. 656 - 664 |
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| Autores principales: | , , , , , , , , , |
| Formato: | equations & formulas research tables/charts Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
2011 Aug
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=108241286&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 108241286 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0954691X 8CE jtl: European Journal of Gastroenterology & Hepatology issn: 0954691X maglogo: N pubinfo: dt: 2011 Aug vid: 23 iid: 8 pid: 5086 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 108241286 108241286 2011214057 10.1097/MEG.0b013e328347c231 NLM21629122 108241286 ppf: 656 ppct: 8 formats: tig: atl: Inverse correlation between allergy markers and Helicobacter pylori infection in children is associated with elevated levels of TGF-[beta]. aug: au: Serrano, Carolina A Talesnik, Eduardo Peña, Alfredo Rollán, Antonio Duarte, Ignacio Torres, Javiera Majerson, Daniela Einisman, Helly Viviani, Paola Harris, Paul R affil: aDivision of Pediatrics bDepartments of Pathology cGastroenterology dPublic Health, Pontificia Universidad Católica de Chile School of Medicine eDr Sótero del Río Hospital, Santiago, Chile. sug: subj: Helicobacter Infections In Infancy and Childhood Hypersensitivity Diagnosis Stomach Anatomy and Histology Adolescence Adult Biopsy Chi Square Test Child Endoscopy Enzyme-Linked Immunosorbent Assay Female Fisher's Exact Test Funding Source Human Male Mann-Whitney U Test Middle Age T-Tests Adolescent: 13-18 years Adult: 19-44 years Child: 6-12 years Middle Aged: 45-64 years Female Male ab: OBJECTIVES: We evaluated allergy/hypersensitivity clinical markers and their correlation with Helicobactor pylori infection in children and adults to analyze how early acquisition of H. pylori could modulate allergic disorder expression. PATIENTS AND METHODS: H. pylori presence was assessed by the rapid urease test and histology of antrum biopsies in 165 patients. Skin tests, serum IgE, and two clinical allergy questionnaires were performed. Allergy severity was operationally defined using a combined score. Findings were correlated with H. pylori status and cytotoxin-associated gene A presence in pediatric and adult patients. Transforming growth factor [beta] (TGF-[beta]) levels were measured by an enzyme-linked immunosorbent assay in serum and gastric biopsies of H. pylori (+) patients. RESULTS: H. pylori (-) children had more positive skin tests to a higher number of antigens than H. pylori (+) children (P<0.05). Operationally defined allergy inversely correlates with H. pylori infection in children, but not in adults. The percentage of H. pylori infection was lower in children with severe allergy (32.3%) compared with children with mild allergy (43.4%) or no allergy (64.3%) (P<0.05). Colonization with virulent strains (cytotoxin-associated gene A+) showed a nonsignificant inverse correlation with severity of allergies in pediatric patients. H. pylori-infected children, but not adults, without allergy markers showed increased levels of TGF-[beta] compared with allergic children both in serum and gastric mucosa (P<0.05). CONCLUSION: There was a strong inverse correlation between allergy markers and H. pylori infection in pediatric patients associated with elevated levels of TGF-[beta] locally and systemically. H. pylori-associated chronic gastritis might downregulate clinical allergy expression. pubtype: Academic Journal doctype: equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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