Helicobacter pylori infection and fundic gastric atrophy are not associated with esophageal squamous cell carcinoma: a case-control study.
OBJECTIVE: Recent studies from Asia and Northern Europe suggest that apart from alcohol intake and smoking, fundic gastric atrophy (FGA) may also increase the risk of esophageal squamous cell carcinoma (OSCC). However, because of the wide geographic variation of this cancer and the changing prevalen...
| Publicado en: | European Journal of Gastroenterology & Hepatology Vol. 23; no. 10; pp. 859 - 865 |
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| Autores principales: | , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
2011 Oct
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=108260578&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 108260578 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0954691X 8CE jtl: European Journal of Gastroenterology & Hepatology issn: 0954691X maglogo: N pubinfo: dt: 2011 Oct vid: 23 iid: 10 pid: 5086 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 108260578 108260578 2011283606 10.1097/MEG.0b013e3283496469 NLM21811162 108260578 ppf: 859 ppct: 6 formats: tig: atl: Helicobacter pylori infection and fundic gastric atrophy are not associated with esophageal squamous cell carcinoma: a case-control study. aug: au: Venerito, Marino Kohrs, Sabine Wex, Thomas Adolf, Daniela Kuester, Doerthe Schubert, Daniel Peitz, Ulrich Mönkemüller, Klaus Malfertheiner, Peter affil: Departments of aGastroenterology, Hepatology and Infectious Diseases bBiometrics and Medical Informatics cSurgery dInstitute of Pathology, Otto-von-Guericke University, Magdeburg, Germany. sug: subj: Atrophy Esophageal Neoplasms Risk Factors Helicobacter Infections Neoplasms, Squamous Cell Risk Factors Stomach Aged Aged, 80 and Over Biopsy Case Control Studies Confidence Intervals Data Analysis Software Descriptive Statistics Epidemiology Ethanol Adverse Effects Female Fisher's Exact Test Germany Human Male Middle Age Odds Ratio Post Hoc Analysis Smoking Complications T-Tests Urease Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Female Male ab: OBJECTIVE: Recent studies from Asia and Northern Europe suggest that apart from alcohol intake and smoking, fundic gastric atrophy (FGA) may also increase the risk of esophageal squamous cell carcinoma (OSCC). However, because of the wide geographic variation of this cancer and the changing prevalence of the Helicobacter pylori infection, these findings need to be confirmed in other ethnic groups. The aim of this case-control study was to investigate whether H. pylori infection and FGA carry an increased risk for OSCC. PATIENTS AND METHODS: FGA was evaluated, by histology and serology, in 75 patients with OSCC, and 75 sex-matched and age-matched controls. Pepsinogen (PG) I levels 70 [mu]g/ml or less and PG I/II ratio of 3 or less were indicative for FGA. H. pylori infection was defined as positivity to at least one test among histology, rapid urease test, and serology for both general anti-IgG and anti-CagA. RESULTS: Overall, the prevalence of H. pylori infection was identically high (70.7%) in both patients with OSCC and controls. FGA diagnosed by serology and histology was not associated with an increased risk for OSCC [odds ratio (OR)=1.17; 95% confidence interval (CI)=0.54-2.56 and OR=1.91; 95% CI=0.6-5.99, respectively]. ORs (95% CI) for hazardous alcohol consumption, smoking, and the presence of both risk factors were 5.75 (2.20-15.05), 22.18 (9.41-52.28), and 31.69 (8.39-119.67), respectively. CONCLUSIONS: Hazardous alcohol consumption and smoking increase synergistically the risk for developing OSCC. In our population neither H. pylori infection nor FGA was associated with an increased risk for OSCC. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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