Muscular forces affect the glycosaminoglycan content of joint cartilage.
Background and purpose - Unloading alters the thickness of joint cartilage. It is unknown, however, to what extent unloading leads to a loss of glycosaminoglycans (GAGs) in the cartilage tissue. We hypothesized that muscle forces, in addition to axial loading, are necessary to maintain the joint car...
| Published in: | Acta Orthopaedica Vol. 86; no. 3; pp. 388 - 393 |
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| Main Authors: | , , , , , , , , |
| Format: | diagnostic images pictorial research tables/charts Journal Article |
| Published: |
Medical Journals Sweden AB
Jun2015
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=108310206&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 108310206 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 17453674 1BVL jtl: Acta Orthopaedica issn: 17453674 maglogo: N pubinfo: dt: Jun2015 vid: 86 iid: 3 pid: 59195 pub: Medical Journals Sweden AB artinfo: ui: 108310206 108310206 108310206 10.3109/17453674.2014.989382 108310206 ppf: 388 ppct: 5 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Muscular forces affect the glycosaminoglycan content of joint cartilage. aug: au: Ganse, Bergita Zange, Jochen Weber, Tobias Pohle-Fröhlich, Regina W Johannes, Bernd Hackenbroch, Matthias Rittweger, Jörn Eysel, Peer Koy, Timmo affil: Division Space Physiology, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne sug: subj: Glycosaminoglycans Knee Joint Physiology Ankle Joint Physiology Cartilage, Articular Physiology Muscles Physiology Stress, Mechanical Biomechanics Orthoses Utilization Human Male Descriptive Statistics Young Adult Adult Middle Age Magnetic Resonance Imaging Data Analysis Software Adult: 19-44 years Middle Aged: 45-64 years Male ab: Background and purpose - Unloading alters the thickness of joint cartilage. It is unknown, however, to what extent unloading leads to a loss of glycosaminoglycans (GAGs) in the cartilage tissue. We hypothesized that muscle forces, in addition to axial loading, are necessary to maintain the joint cartilage GAG content of the knee and the upper and lower ankle. Patients and methods - The HEPHAISTOS orthosis was worn unilaterally by 11 men (mean age 31 (23-50) years old) for 56 days. The orthosis reduces activation and force production of the calf muscles while it permits full gravitational loading of the lower leg. MRI measurements of the knee and ankle were taken before the intervention, during the intervention (on day 49), and 14 days after the end of the intervention. Cartilage segmentation was conducted semiautomatically for the knee joint (4 segments) and for the upper (tibio-talar) and lower (subtalar) ankle joints (2 segments each). Linear mixed-effects (LME) models were used for statistical analysis. Results - 8 volunteers completed the MRI experiment. In the lower ankle joint, differences in ΔT1 were found between the end of the intervention and 14 days after (p = 0.004), indicating a decrease in GAG content after reloading. There were no statistically significant differences in ΔT1 values in the knee and upper ankle joints. Interpretation - Our findings suggest that in addition to gravitational load, muscular forces affect cartilage composition depending on the local distribution of forces in the joints affected by muscle contraction. pubtype: Academic Journal doctype: diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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