Maternal supplementation of α-linolenic acid in normal and protein-restricted diets modulate lipid metabolism, adipose tissue growth and leptin levels in the suckling offspring.
Background: Lipid quantity and quality have been shown to affect serum cholesterol, adipose and serum leptin levels during prenatal and postnatal dietary supplementation of adult rats. Maternal protein deficiency during pregnancy and lactation also affects polyunsaturated fatty acid (PUFA) levels in...
| Publicado en: | European Journal of Nutrition Vol. 54; no. 5; pp. 761 - 771 |
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| Autores principales: | , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Aug2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=108329870&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 108329870 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Aug2015 vid: 54 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 108329870 109830643 109830643 10.1007/s00394-014-0755-3 108329870 ppf: 761 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Maternal supplementation of α-linolenic acid in normal and protein-restricted diets modulate lipid metabolism, adipose tissue growth and leptin levels in the suckling offspring. aug: au: Reddy, K. Naidu, K. affil: Department of Biochemistry and Nutrition, CSIR-Central Food Technological Research Institute, Mysore 570020 India sug: subj: alpha-Linolenic Acid Administration and Dosage Fatty Acids, omega-3 Metabolism Cholesterol Blood Leptin Blood Adipose Tissue Metabolism Dietary Proteins Deficiency Pregnancy Outcomes Animal Studies In Vivo Studies Maternal Nutritional Physiology India Funding Source Rats Pregnancy Female Fetus Infant, Newborn Restricted Diet Dietary Supplementation Triglycerides Blood Liver Function Tests Histological Techniques Cholesterol Analysis Immunoassay Descriptive Statistics One-Way Analysis of Variance Post Hoc Analysis P-Value Data Analysis Software Fetus, conception to birth Infant, Newborn: birth-1 month Female ab: Background: Lipid quantity and quality have been shown to affect serum cholesterol, adipose and serum leptin levels during prenatal and postnatal dietary supplementation of adult rats. Maternal protein deficiency during pregnancy and lactation also affects polyunsaturated fatty acid (PUFA) levels in the offspring. The aim of the present study was to analyze the effect of α-linolenic acid (ALA; n-3) on n-3 PUFA accretion, lipid profile, leptin levels and adipose growth in normal and protein-restricted (deficient) dams and their suckling pups. Methods: Garden cress oil rich in ALA (32 %) was supplemented in the normal and protein-restricted (10 %) diets and fed to rats for 8 weeks prior to gestation and during lactation. PUFA, cholesterol, triglycerides, leptin levels and retroperitoneal white adipose tissue weight (WAT) of the dams and the pups were analyzed at 3 weeks after delivery. Results: The serum cholesterol levels were remarkably decreased ( p < 0.01), and the n-3 PUFA levels were markedly increased ( p < 0.05) in the pups of lactating normal and protein-deficient dams supplemented with ALA. Triglycerides were unaltered in the dams and the pups of different dietary groups. Serum leptin levels and relative WAT weights were lower ( p < 0.01) in the pups of the ALA-supplemented normal and protein-deficient dams. Conclusion: Maternal supplementation of ALA in normal and protein-restricted diets modulates n-3 PUFA levels, cholesterol, leptin levels and also adipose growth in the suckling offspring. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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