Latent structure of cognition in schizophrenia: a confirmatory factor analysis of the MATRICS Consensus Cognitive Battery (MCCB).
BackgroundThe number of separable cognitive dimensions in schizophrenia has been debated. Guided by the extant factor analytic literature, the NIMH Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) initiative selected seven cognitive domains relevant to treatment stu...
| Publicado en: | Psychological Medicine Vol. 45; no. 12; pp. 2657 - 2667 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Cambridge University Press
Sep2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=108714355&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 108714355 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00332917 6Q3 jtl: Psychological Medicine issn: 00332917 maglogo: N pubinfo: dt: Sep2015 vid: 45 iid: 12 pid: 15979 pub: Cambridge University Press artinfo: ui: 108714355 109823272 109823272 10.1017/S0033291715000641 108714355 ppf: 2657 ppct: 10 formats: tig: atl: Latent structure of cognition in schizophrenia: a confirmatory factor analysis of the MATRICS Consensus Cognitive Battery (MCCB). aug: au: McCleery, A. Green, M. F. Hellemann, G. S. Baade, L. E. Gold, J. M. Keefe, R. S. E. Kern, R. S. Mesholam-Gately, R. I. Seidman, L. J. Subotnik, K. L. Ventura, J. Nuechterlein, K. H. affil: Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA sug: subj: Neuropsychological Tests Evaluation Cognition Schizophrenia Instrument Validation Human Latent Structure Analysis Factor Analysis Validation Studies Outpatients Comparative Studies Memory Mental Processes Descriptive Statistics Adult Male Female Schizophrenia Drug Therapy Risperidone Administration and Dosage Interview Guides Data Analysis Software Algorithms Chi Square Test Funding Source Adult: 19-44 years Male Female ab: BackgroundThe number of separable cognitive dimensions in schizophrenia has been debated. Guided by the extant factor analytic literature, the NIMH Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) initiative selected seven cognitive domains relevant to treatment studies in schizophrenia: speed of processing, attention/vigilance, working memory, verbal learning, visual learning, reasoning and problem solving, and social cognition. These domains are assessed in the MATRICS Consensus Cognitive Battery (MCCB). The aim of this study was to conduct a confirmatory factor analysis (CFA) of the beta battery of the MCCB to compare the fit of the MATRICS consensus seven-domain model to other models in the current literature on cognition in schizophrenia.MethodUsing data from 281 schizophrenia outpatients, we compared the seven correlated factors model with alternative models. Specifically, we compared the 7-factor model to (a) a single-factor model, (b) a three correlated factors model including speed of processing, working memory, and general cognition, and (c) a hierarchical model in which seven first-order factors loaded onto a second-order general cognitive factor.ResultsMultiple fit indices indicated the seven correlated factors model was the best fit for the data and provided significant improvement in model fit beyond the comparison models.ConclusionsThese results support the assessment of these seven cognitive dimensions in clinical trials of interventions to improve cognition in schizophrenia. Because these cognitive factors are separable to some degree, it is plausible that specific interventions may have differential effects on the domains. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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