Isolation, structure elucidation and enzyme inhibition studies of a new hydroxy ester and other compounds from Berberis jaeschkeana Schneid stem.
Bioassay-guided isolation and fractionation ofBerberis jaeschkeanaSchneid var.jaeschkeanastem resulted in the isolation and characterisation of a new long chain hydroxy ester named as berberinol (1) along with six known compounds (2–7). All the structures were established from 1D and 2D spectroscopi...
| Publicado en: | Natural Product Research Vol. 29; no. 17; pp. 1664 - 1670 |
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| Autores principales: | , , , , |
| Formato: | Journal Article |
| Publicado: |
Taylor & Francis Ltd
Sep2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| Sumario: | Bioassay-guided isolation and fractionation ofBerberis jaeschkeanaSchneid var.jaeschkeanastem resulted in the isolation and characterisation of a new long chain hydroxy ester named as berberinol (1) along with six known compounds (2–7). All the structures were established from 1D and 2D spectroscopic data. Crude extract, sub-fractions and all the isolated compounds were evaluated for their anti-fungal and urease enzyme inhibition properties. All of the sub-fractions and compounds showed good anti-fungal and urease enzyme inhibition properties. Minimum inhibitory concentrations (MICs) were calculated for all active samples in case of urease enzyme inhibition. MICs values were found to be in the range of 39.03–49.78 μg/mL for urease enzyme inhibition. |
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