Mechanism of Oxygen Activation in a Flavin-Dependent Monooxygenase: A Nearly Barrierless Formation of C4a-Hydroperoxyflavin via Proton-Coupled Electron Transfer.

Understanding how flavin-dependent enzymes activate oxygen for their oxidation and oxygenation reactions is one of the most challenging issues in flavoenzymology. Density functional calculations and transient kinetics were performed to investigate the mechanism of oxygen activation in the oxygenase...

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Bibliographic Details

Published in:	Journal of the American Chemical Society Vol. 137; no. 29; pp. 9363 - 9375
Main Authors:	Visitsatthawong, Surawit, Chenprakhon, Pirom, Chaiyen, Pimchai, Surawatanawong, Panida
Format:	Article
Published:	American Chemical Society 7/29/2015
Subjects:	Activation (Chemistry) Flavins Monooxygenases Hydroperoxides Charge exchange Proton-proton interactions
Online Access:	View this record in EBSCOhost