Ruthenium-Catalyzed Formal Dehydrative [4 + 2] Cycloaddition of Enamides and Alkynes for the Synthesis of Highly Substituted Pyridines: Reaction Development and Mechanistic Study.

Reported herein is a ruthenium-catalyzed formal dehydrative [4 + 2] cycloaddition of enamides and alkynes, representing a mild and economic protocol for the construction of highly substituted pyridines. Notably, the features of broad substrate scope, high efficiency, good functional group tolerance,...

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Publicado en:	Journal of the American Chemical Society Vol. 137; no. 29; pp. 9489 - 9497
Autores principales:	Jicheng Wu, Wenbo Xu, Zhi-Xiang Yu, Jian Wang
Formato:	Artículo
Publicado:	American Chemical Society 7/29/2015
Materias:	Ruthenium catalysts Ring formation (Chemistry) Alkynes Pyridine Density functional theory
Acceso en línea:	Ver este registro en EBSCOhost