Moderate Dietary Supplementation with Omega-3 Fatty Acids Does Not Impact Plasma Von Willebrand Factor Profile in Mildly Hypertensive Subjects.
Long chain omega-3 polyunsaturated fatty acids (LC n-3 PUFAs) have blood pressure lowering and antithrombotic effects, which may benefit hypertensive patients. Increased plasma concentration of von Willebrand factor (vWF), a procoagulant glycoprotein, has been identified in patients with severe hype...
| Published in: | BioMed Research International Vol. 2015; pp. 1 - 9 |
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| Main Authors: | , , , |
| Format: | clinical trial pictorial research tables/charts Journal Article |
| Published: |
Wiley-Blackwell
8/2/2015
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109030950&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109030950 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 8/2/2015 vid: 2015 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 109030950 109030950 109030950 10.1155/2015/394871 109030950 ppf: 1 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Moderate Dietary Supplementation with Omega-3 Fatty Acids Does Not Impact Plasma Von Willebrand Factor Profile in Mildly Hypertensive Subjects. aug: au: Bürgin-Maunder, Corinna S. Brooks, Peter R. Hitchen-Holmes, Deborah Russell, Fraser D. affil: Inflammation and Healing Research Cluster, University of the Sunshine Coast, Maroochydore, 4556 QLD, Australia sug: subj: Fatty Acids, omega-3 Therapeutic Use Blood Coagulation Factors Blood Hypertension Human Academic Medical Centers Funding Source Queensland Clinical Trials Enzyme-Linked Immunosorbent Assay Analysis of Variance Post Hoc Analysis T-Tests Data Analysis Software Adult Descriptive Statistics Male Female Middle Age Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Long chain omega-3 polyunsaturated fatty acids (LC n-3 PUFAs) have blood pressure lowering and antithrombotic effects, which may benefit hypertensive patients. Increased plasma concentration of von Willebrand factor (vWF), a procoagulant glycoprotein, has been identified in patients with severe hypertension, with some, but not all studies showing an increase with mild hypertension. In this study, we determined the plasma concentration, multimer distribution, and collagen binding activity of vWF in subjects with mild hypertension and determined whether these parameters might improve after dietary supplementation with moderate amounts of LC n-3 PUFAs. Hypertensive and normotensive subjects were randomized to 12-week treatment with LC n-3 PUFAs (2.52 g/day) or placebo (canola oil). Home blood pressure measurements were recorded daily, and blood samples were collected every 3 weeks. LC n-3 PUFAs increased the n-3 index to cardioprotective levels (>8%). Plasma concentration, multimer distribution, and collagen binding activity of vWF were not reduced by LC n-3 PUFA treatment. We conclude that, at the concentration and duration used in this study, benefits of LC n-3 PUFAs in subjects with mild hypertension are not associated with a direct effect on vWF concentration or function. This trial is registered with the Australian New Zealand Clinical Trials Registry <ext-link>ACTRN12610000713099</ext-link>. pubtype: Academic Journal doctype: clinical trial pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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