Integration of DCE-MRI and DW-MRI Quantitative Parameters for Breast Lesion Classification.
Objective. The purpose of our study was to evaluate the diagnostic value of an imaging protocol combining dynamic contrast-enhanced MRI (DCE-MRI) and diffusion-weighted MRI (DW-MRI) in patients with suspicious breast lesions. Materials and Methods. A total of 31 breast lesions (15 malignant and 16 b...
| Publicado en: | BioMed Research International Vol. 2015; pp. 1 - 13 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | equations & formulas research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
8/3/2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109030971&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109030971 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 8/3/2015 vid: 2015 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 109030971 109030971 109030971 10.1155/2015/237863 109030971 ppf: 1 ppct: 12 formats: fmt: @attributes: type: P tig: atl: Integration of DCE-MRI and DW-MRI Quantitative Parameters for Breast Lesion Classification. aug: au: Fusco, Roberta Sansone, Mario Filice, Salvatore Granata, Vincenza Catalano, Orlando Amato, Daniela Maria Di Bonito, Maurizio D’Aiuto, Massimiliano Capasso, Immacolata Rinaldo, Massimo Petrillo, Antonella affil: Department of Diagnostic Imaging, Radiant and Metabolic Therapy, “Istituto Nazionale Tumori Fondazione Giovanni Pascale, IRCCS”, Via Mariano Semmola, 80131 Naples, Italy sug: subj: Breast Neoplasms Diagnosis Breast Neoplasms Classification Magnetic Resonance Imaging Methods Contrast Media Diagnostic Use Quantitative Studies Human Breast Neoplasms Pathology Sensitivity and Specificity Comparative Studies Female Adolescence Adult Middle Age Italy Spearman's Rank Correlation Coefficient Discriminant Analysis ROC Curve Algorithms Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Female ab: Objective. The purpose of our study was to evaluate the diagnostic value of an imaging protocol combining dynamic contrast-enhanced MRI (DCE-MRI) and diffusion-weighted MRI (DW-MRI) in patients with suspicious breast lesions. Materials and Methods. A total of 31 breast lesions (15 malignant and 16 benign proved by histological examination) in 26 female patients were included in this study. For both DCE-MRI and DW-MRI model free and model based parameters were computed pixel by pixel on manually segmented ROIs. Statistical procedures included conventional linear analysis and more advanced techniques for classification of lesions in benign and malignant. Results. Our findings indicated no strong correlation between DCE-MRI and DW-MRI parameters. Results of classification analysis show that combining of DCE parameters or DW-MRI parameter, in comparison of single feature, does not yield a dramatic improvement of sensitivity and specificity of the two techniques alone. The best performance was obtained considering a full combination of all features. Moreover, the classification results combining all features are dominated by DCE-MRI features alone. Conclusion. The combination of DWI and DCE-MRI does not show a potential to dramatically increase the sensitivity and specificity of breast MRI. DCE-MRI alone gave the same performance as in combination with DW-MRI. pubtype: Academic Journal doctype: equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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