The association of brain structure with gait velocity in older adults: a quantitative volumetric analysis of brain MRI.
Introduction: While cortical processes play an important role in controlling locomotion, the underlying structural brain changes associated with slowing of gait in aging are not yet fully established. Our study aimed to examine the relationship between cortical gray matter volume (GM), white matter...
| Publicado en: | Neuroradiology Vol. 57; no. 8; pp. 851 - 862 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Aug2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109136715&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109136715 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Aug2015 vid: 57 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 109136715 109136715 109136715 10.1007/s00234-015-1536-2 109136715 ppf: 851 ppct: 11 formats: fmt: @attributes: type: P tig: atl: The association of brain structure with gait velocity in older adults: a quantitative volumetric analysis of brain MRI. aug: au: Ezzati, Ali Katz, Mindy Lipton, Michael Lipton, Richard Verghese, Joe affil: Saul B. Korey Department of Neurology, Albert Einstein College of Medicine of Yeshiva University, Rousso Bldg. Rm. 330, 1165 Morris Park Avenue Bronx 10461 USA sug: subj: Brain Anatomy and Histology Gait Analysis In Old Age Magnetic Resonance Imaging Methods Aging Human Cognition Descriptive Statistics Aged Aged, 80 and Over Data Analysis Software Linear Regression Memory Hippocampus Gray Matter Cerebral Ventricles Aged: 65+ years Aged, 80 & over ab: Introduction: While cortical processes play an important role in controlling locomotion, the underlying structural brain changes associated with slowing of gait in aging are not yet fully established. Our study aimed to examine the relationship between cortical gray matter volume (GM), white matter volume (WM), ventricular volume (VV), hippocampal and hippocampal subfield volumes, and gait velocity in older adults free of dementia. Methods: Gait and cognitive performance was tested in 112 community-residing adults, age 70 years and over, participating in the Einstein Aging Study. Gait velocity (cm/s) was obtained using an instrumented walkway. Volumetric MRI measures were estimated using a FreeSurfer software. We examined the cross-sectional relationship of GM, WM, VV, and hippocampal total and subfield volumes and gait velocity using linear regression models. In complementary models, the effect of memory performance on the relationship between gait velocity and regional volumes was evaluated. Results: Slower gait velocity was associated with smaller cortical GM and total hippocampal volumes. There was no association between gait velocity and WM or VV. Among hippocampal subfields, only smaller presubiculum volume was significantly associated with decrease in gait velocity. Addition of the memory performance to the models attenuated the association between gait velocity and all volumetric measures. Conclusions: Our findings indicate that total GM and hippocampal volumes as well as specific hippocampal subfield volumes are inversely associated with locomotor function. These associations are probably affected by cognitive status of study population. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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