RETRACTED ARTICLE: A study on cognitive impairment and gray matter volume abnormalities in silent cerebral infarction patients.
Introduction: The relationship between silent cerebral infarction (SCI) and the integrity of cognitive function is unknown. We intended to investigate whether cognitive impairment is associated with gray matter volume (GMV) in the SCI patients. Methods: Sixty-two patients with SCI and 62 age- and ge...
| Publicado en: | Neuroradiology Vol. 57; no. 8; pp. 783 - 790 |
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| Autores principales: | , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Aug2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109136716&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109136716 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Aug2015 vid: 57 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 109136716 109136716 109136716 10.1007/s00234-015-1535-3 109136716 ppf: 783 ppct: 7 formats: fmt: @attributes: type: P tig: atl: RETRACTED ARTICLE: A study on cognitive impairment and gray matter volume abnormalities in silent cerebral infarction patients. aug: au: Luo, Wei Jiang, Xun Wei, Xiaofeng Li, Shanshan Li, Mengxiong affil: Biomedical Engineering Laboratory, The First Affiliated Hospital of Yangtze University, Jingzhou People's Republic of China sug: subj: Cognition Disorders Etiology Cerebral Ischemia Complications Gray Matter Physiopathology Brain Pathology Human Descriptive Statistics Age Factors Sex Factors Psychological Tests Magnetic Resonance Imaging Methods Data Analysis Software Educational Status Hamilton Rating Scale for Depression Scales Cerebral Ischemia Pathology Brain Radiography ab: Introduction: The relationship between silent cerebral infarction (SCI) and the integrity of cognitive function is unknown. We intended to investigate whether cognitive impairment is associated with gray matter volume (GMV) in the SCI patients. Methods: Sixty-two patients with SCI and 62 age- and gender-matched healthy controls (HC) were evaluated with P300 test, Montreal Cognitive Assessment (MoCA) test, Hamilton Anxiety Scale (HAMA), and Hamilton Depression Scale (HDRS). Whole brain high-resolution T1-weighted images were processed with SPM12b software and analyzed by voxel-based morphometry (VBM). Correlation analysis was performed between the GMV and the scores of MoCA Scale, P300 latency, P300 amplitude, HAMA, HDRS, age, and educational level. Results: The brains of the SCI patients have a significant reduction in GMV in the left superior and inferior frontal gyrus, left superior temporal gyrus, right middle temporal gyrus, and bilateral hippocampus gyrus ( p < 0.01, FDR correction). No significant increase of GMV was detected. The GMV of their frontal and temporal lobes is positively correlated with the score of MoCA scale and P300 amplitude ( r ≥ 0.62, p < 0.01). The GMV of frontal, temporal, and hippocampus is negatively correlated with P300 latency ( r ≤ −0.71, p < 0.05). No significant correlation between the GMV of abnormal brain regions and another two clinical characteristics was found. Conclusion: SCI patients have impaired cognitive function and reduced GMV compared to the HC subjects. The neuropathological basis of such cognitive deficits in SCI patients might be a reduced GMV. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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