Genepleio Software for Effective Estimation of Gene Pleiotropy from Protein Sequences.
Though pleiotropy, which refers to the phenomenon of a gene affecting multiple traits, has long played a central role in genetics, development, and evolution, estimation of the number of pleiotropy components remains a hard mission to accomplish. In this paper, we report a newly developed software p...
| Publicado en: | BioMed Research International Vol. 2015; pp. 1 - 7 |
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| Autores principales: | , , , , , |
| Formato: | equations & formulas pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
1/5/2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109273008&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109273008 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 1/5/2015 vid: 2015 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 109273008 109273008 109273008 10.1155/2015/269150 109273008 ppf: 1 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Genepleio Software for Effective Estimation of Gene Pleiotropy from Protein Sequences. aug: au: Chen, Wenhai Chen, Dandan Zhao, Ming Zou, Yangyun Zeng, Yanwu Gu, Xun affil: College of Mathematics & Information Science, Wenzhou University, Wenzhou, China sug: subj: Genes Evaluation Data Analysis Software Validity Human Academic Medical Centers China ab: Though pleiotropy, which refers to the phenomenon of a gene affecting multiple traits, has long played a central role in genetics, development, and evolution, estimation of the number of pleiotropy components remains a hard mission to accomplish. In this paper, we report a newly developed software package, Genepleio, to estimate the effective gene pleiotropy from phylogenetic analysis of protein sequences. Since this estimate can be interpreted as the minimum pleiotropy of a gene, it is used to play a role of reference for many empirical pleiotropy measures. This work would facilitate our understanding of how gene pleiotropy affects the pattern of genotype-phenotype map and the consequence of organismal evolution. pubtype: Academic Journal doctype: equations & formulas pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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