Conformational B-Cell Epitope Prediction Method Based on Antigen Preprocessing and Mimotopes Analysis.
Identification of epitopes which invokes strong humoral responses is an essential issue in the field of immunology. Various computational methods that have been developed based on the antigen structures and the mimotopes these years narrow the search for experimental validation. These methods can be...
| Publicado en: | BioMed Research International Vol. 2015; pp. 1 - 9 |
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| Autores principales: | , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
1/29/2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109273273&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109273273 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 1/29/2015 vid: 2015 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 109273273 109273273 109273273 10.1155/2015/257030 109273273 ppf: 1 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Conformational B-Cell Epitope Prediction Method Based on Antigen Preprocessing and Mimotopes Analysis. aug: au: Sun, Pingping Ju, Haixu Zhang, Baowen Gu, Yu Liu, Bo Huang, Yanxin Zhang, Huijie Li, Yuxin affil: School of Computer Science and Information Technology, Northeast Normal University, Changchun 130117, China sug: subj: B Lymphocytes Antigens Analysis Immunity, Cellular Peptides Analysis Antigens Classification Descriptive Statistics Antibody Formation Algorithms Sensitivity and Specificity Correlation Coefficient Validity Precision Funding Source ab: Identification of epitopes which invokes strong humoral responses is an essential issue in the field of immunology. Various computational methods that have been developed based on the antigen structures and the mimotopes these years narrow the search for experimental validation. These methods can be divided into two categories: antigen structure-based methods and mimotope-based methods. Though new methods of the two kinds have been proposed in these years, they cannot maintain a high degree of satisfaction in various circumstances. In this paper, we proposed a new conformational B-cell epitope prediction method based on antigen preprocessing and mimotopes analysis. The method classifies the antigen surface residues into “epitopes” and “nonepitopes” by six epitope propensity scales, removing the “nonepitopes” and using the preprocessed antigen for epitope prediction based on mimotope sequences. The proposed method gives out the mean F score of 0.42 on the testing dataset. When compared with other publicly available servers by using the testing dataset, the new method yields better performance. The results demonstrate the proposed method is competent for the conformational B-cell epitope prediction. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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