Expression of MMP-9 and VEGF in Meningiomas and Their Correlation with Peritumoral Brain Edema.
Meningiomas constitute up to 13% of all intracranial tumors. The predictive factors for meningioma have not been unambiguously defined; however some limited data suggest that the expression of matrix metalloproteinases (MMPs) and vascular endothelial growth factor (VEGF) may be associated with the p...
| Publicado en: | BioMed Research International Vol. 2015; pp. 1 - 9 |
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| Autores principales: | , , , , , |
| Formato: | diagnostic images pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
3/3/2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109273563&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109273563 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 3/3/2015 vid: 2015 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 109273563 109273563 109273563 10.1155/2015/646853 109273563 ppf: 1 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Expression of MMP-9 and VEGF in Meningiomas and Their Correlation with Peritumoral Brain Edema. aug: au: Reszec, Joanna Hermanowicz, Adam Rutkowski, Robert Turek, Grzegorz Mariak, Zenon Chyczewski, Lech affil: Department of Medical Pathomorphology, Medical University of Bialystok, Ulica Waszyngtona 13, 15-269 Bialystok, Poland sug: subj: Meningioma Physiopathology Enzymes Growth Substances Cerebral Edema Physiopathology Human Immunohistochemistry Gene Expression Poland Academic Medical Centers Retrospective Design Data Analysis Software Kruskal-Wallis Test Male Female Adult Middle Age Aged Aged, 80 and Over Descriptive Statistics Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Male Female ab: Meningiomas constitute up to 13% of all intracranial tumors. The predictive factors for meningioma have not been unambiguously defined; however some limited data suggest that the expression of matrix metalloproteinases (MMPs) and vascular endothelial growth factor (VEGF) may be associated with the presence of peritumoral brain edema (PTBE) and worse clinical outcome. The aim of this study was to analyze the expressions of MMP-9 and VEGF in a group of meningiomas of various grades and to study associations between these two markers and PTBE. The study included patients with supratentorial meningiomas. The patients were divided into low- (G1) and high-grade meningiomas (G2 and G3). PTBE was assessed on MRI. The expressions of VEGF and MMP-9 were determined immunohistochemically. The expression of MMP-9 was observed significantly more often in G3 meningiomas than in lower grade tumors. The presence of stage II or III PTBE was associated with a significant increase in MMP-9 expression. The expression of VEGF did not differ across the PTBE stages. Our findings point to a significant role of MMP-9 and VEGF in the pathogenesis of peritumoral brain edema in low- and high-grade meningiomas. pubtype: Academic Journal doctype: diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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