Diagnostic Value of MRI Proton Density Fat Fraction for Assessing Liver Steatosis in Chronic Viral C Hepatitis.
Objective. To assess the diagnostic performance of a T1-independent, T2*-corrected multiecho magnetic resonance imaging (MRI) technique for the quantification of hepatic steatosis in a cohort of patients affected by chronic viral C hepatitis, using liver biopsy as gold standard. Methods. Eighty-one...
| Published in: | BioMed Research International Vol. 2015; pp. 1 - 12 |
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| Main Authors: | , , , , , , , , , , , |
| Format: | diagnostic images equations & formulas research tables/charts Journal Article |
| Published: |
Wiley-Blackwell
3/19/2015
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109273704&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109273704 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 3/19/2015 vid: 2015 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 109273704 109273704 109273704 10.1155/2015/758164 109273704 ppf: 1 ppct: 11 formats: fmt: @attributes: type: P tig: atl: Diagnostic Value of MRI Proton Density Fat Fraction for Assessing Liver Steatosis in Chronic Viral C Hepatitis. aug: au: Paparo, Francesco Cenderello, Giovanni Revelli, Matteo Bacigalupo, Lorenzo Rutigliani, Mariangela Zefiro, Daniele Cevasco, Luca Amico, Maria Bandelloni, Roberto Cassola, Giovanni Forni, Gian Luca Rollandi, Gian Andrea affil: Department of Radiology, E.O. Ospedali Galliera, Mura della Cappuccine 14, 16128 Genoa, Italy sug: subj: Hepatitis C, Chronic Complications Liver Pathology Magnetic Resonance Imaging Utilization Fatty Liver Diagnosis Fatty Liver Radiography Biopsy Ultrasonography Protons Radiographic Image Enhancement Fibrosis Classification Inflammation Classification Fatty Liver Classification Hepatitis C, Chronic Pathology Prospective Studies T-Tests Regression Predictive Value of Tests P-Value Confidence Intervals Descriptive Statistics ROC Curve Pearson's Correlation Coefficient Spearman's Rank Correlation Coefficient Kruskal-Wallis Test Post Hoc Analysis Sensitivity and Specificity Adolescence Adult Middle Age Aged Aged, 80 and Over Female Male Human Funding Source Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Female Male ab: Objective. To assess the diagnostic performance of a T1-independent, T2*-corrected multiecho magnetic resonance imaging (MRI) technique for the quantification of hepatic steatosis in a cohort of patients affected by chronic viral C hepatitis, using liver biopsy as gold standard. Methods. Eighty-one untreated patients with chronic viral C hepatitis were prospectively enrolled. All included patients underwent MRI, transient elastography, and liver biopsy within a time interval <10 days. Results. Our cohort of 77 patients included 43/77 (55.8%) males and 34/77 (44.2%) females with a mean age of 51.31 ± 11.27 (18–81) years. The median MRI PDFF showed a strong correlation with the histological fat fraction (FF) (r=0.754, 95% CI 0.637 to 0.836, P<0.0001), and the correlation was influenced by neither the liver stiffness nor the T2* decay. The median MRI PDFF result was significantly lower in the F4 subgroup (P<0.05). The diagnostic accuracy of MRI PDFF evaluated by AUC-ROC analysis was 0.926 (95% CI 0.843 to 0.973) for S≥1 and 0.929 (95% CI 0.847 to 0.975) for S=2. Conclusions. Our MRI technique of PDFF estimation allowed discriminating with a good diagnostic accuracy between different grades of hepatic steatosis. pubtype: Academic Journal doctype: diagnostic images equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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