A Fast Neural Network Approach to Predict Lung Tumor Motion during Respiration for Radiation Therapy Applications.

During radiotherapy treatment for thoracic and abdomen cancers, for example, lung cancers, respiratory motion moves the target tumor and thus badly affects the accuracy of radiation dose delivery into the target. A real-time image-guided technique can be used to monitor such lung tumor motion for ac...

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Publicado en:BioMed Research International Vol. 2015; pp. 1 - 14
Autores principales: Bukovsky, Ivo, Homma, Noriyasu, Ichiji, Kei, Cejnek, Matous, Slama, Matous, Benes, Peter M., Bila, Jiri
Formato: equations & formulas research tables/charts Journal Article
Publicado: Wiley-Blackwell 3/29/2015
Acceso en línea:Ver este registro en EBSCOhost
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      dt: 3/29/2015
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      pub: Wiley-Blackwell
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        10.1155/2015/489679
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        atl: A Fast Neural Network Approach to Predict Lung Tumor Motion during Respiration for Radiation Therapy Applications.
      aug:
        au:
          Bukovsky, Ivo
          Homma, Noriyasu
          Ichiji, Kei
          Cejnek, Matous
          Slama, Matous
          Benes, Peter M.
          Bila, Jiri
        affil: Department of Instrumentation and Control Engineering, Faculty of Mechanical Engineering, Czech Technical University in Prague, 16607 Prague, Czech Republic
      sug:
        subj:
          Neural Networks (Computer)
          Respiration
          Movement Evaluation
          Lung Neoplasms Radiotherapy
          Radiotherapy Methods
          Algorithms
          Time Series
          Evaluation Research
          Human
          Funding Source
      ab: During radiotherapy treatment for thoracic and abdomen cancers, for example, lung cancers, respiratory motion moves the target tumor and thus badly affects the accuracy of radiation dose delivery into the target. A real-time image-guided technique can be used to monitor such lung tumor motion for accurate dose delivery, but the system latency up to several hundred milliseconds for repositioning the radiation beam also affects the accuracy. In order to compensate the latency, neural network prediction technique with real-time retraining can be used. We have investigated real-time prediction of 3D time series of lung tumor motion on a classical linear model, perceptron model, and on a class of higher-order neural network model that has more attractive attributes regarding its optimization convergence and computational efficiency. The implemented static feed-forward neural architectures are compared when using gradient descent adaptation and primarily the Levenberg-Marquardt batch algorithm as the ones of the most common and most comprehensible learning algorithms. The proposed technique resulted in fast real-time retraining, so the total computational time on a PC platform was equal to or even less than the real treatment time. For one-second prediction horizon, the proposed techniques achieved accuracy less than one millimeter of 3D mean absolute error in one hundred seconds of total treatment time.
      pubtype: Academic Journal
      doctype:
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        research
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      ougenre: Article
    language: English
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