Magnetic Resonance Comparison of Left-Right Heart Volumetric and Functional Parameters in Thalassemia Major and Thalassemia Intermedia Patients.
Objectives. To evaluate a population of asymptomatic thalassemia major (TM) and thalassemia intermedia (TI) patients using cardiovascular magnetic resonance (CMR). We supposed that TI group could be differentiated from the TM group based on T2∗ and that the TI group could demonstrate higher cardiac...
| Publicado en: | BioMed Research International Vol. 2015; pp. 1 - 8 |
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| Autores principales: | , , , , , , , |
| Formato: | equations & formulas research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
4/2/2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109273876&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109273876 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 4/2/2015 vid: 2015 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 109273876 109273876 109273876 10.1155/2015/857642 109273876 ppf: 1 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Magnetic Resonance Comparison of Left-Right Heart Volumetric and Functional Parameters in Thalassemia Major and Thalassemia Intermedia Patients. aug: au: Liguori, Carlo Pitocco, Francesca Di Giampietro, Ilenia De Vivo, Aldo Eros Schena, Emiliano Giurazza, Francesco Sorrentino, Francesco Zobel, Bruno Beomonte affil: Department of Radiology, A.O.R.N. Cardarelli, Via Antonio Cardarelli 9, 80100 Naples, Italy sug: subj: Thalassemia Complications Heart Physiology Magnetic Resonance Imaging Thalassemia Physiopathology Human Italy Academic Medical Centers Retrospective Design Record Review Male Female Adult Middle Age Thalassemia Classification Thalassemia Epidemiology Severity of Illness Anemia Complications Oxidative Stress Data Analysis Software Linear Regression Spearman's Rank Correlation Coefficient Genomics Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Objectives. To evaluate a population of asymptomatic thalassemia major (TM) and thalassemia intermedia (TI) patients using cardiovascular magnetic resonance (CMR). We supposed that TI group could be differentiated from the TM group based on T2∗ and that the TI group could demonstrate higher cardiac output. Methods. A retrospective analysis of 242 patients with TM and TI was performed (132 males, 110 females; mean age 39.6±8 years; 186 TM, 56 TI). Iron load was assessed by T2∗ measurements; volumetric functions were analyzed using steady-state-free precession sequences. Results. Significant difference in left-right heart performance was observed between TM with iron overload and TI patients and between TM with iron overload and TM without iron overload (P<0.05); no significant differences were observed between TM without iron overload and TI patients. A significant correlation was observed between T2∗ and ejection fraction of right ventricle- (RV-) ejection fraction of left ventricle (LV); an inverse correlation was present among T2∗ values and end-diastolic volume of LV, end-systolic volume of LV, stroke volume of LV, end-diastolic volume of RV, end-systolic volume of RV, and stroke volume of RV. Conclusions. CMR is a leading approach for cardiac risk evaluation of TM and TI patients. pubtype: Academic Journal doctype: equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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