Chitosan Prevents Gentamicin-Induced Nephrotoxicity via a Carbonyl Stress-Dependent Pathway.
Aminoglycosides are widely used to treat infections; however, their applications are limited by nephrotoxicity. With the increase of antibiotic resistance, the use of aminoglycosides is inevitable. Low-molecular-weight chitosan (LMWC) has shown renal protective effects in dialysis patients. However,...
| Publicado en: | BioMed Research International Vol. 2015; pp. 1 - 9 |
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| Autores principales: | , , , , |
| Formato: | equations & formulas pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
4/12/2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109273926&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109273926 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 4/12/2015 vid: 2015 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 109273926 109273926 109273926 10.1155/2015/675714 109273926 ppf: 1 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Chitosan Prevents Gentamicin-Induced Nephrotoxicity via a Carbonyl Stress-Dependent Pathway. aug: au: Chou, Chu-Kung Li, Yi-Chieh Chen, Shih-Ming Shih, Yi-Min Lee, Jen-Ai affil: Department of Internal Medicine, Chia-Yi Christian Hospital, 539 Jhongsiao Road, Chiayi City 60002, Taiwan sug: subj: Chelating Agents Therapeutic Use Hemostatics Therapeutic Use Gentamicins Adverse Effects Nephrotoxicity Prevention and Control Oxidative Stress Kidney Diseases Prevention and Control Dialysis Patients Metformin Administration and Dosage Administration, Oral Animal Studies Models, Biological Creatinine Blood Chelating Agents Administration and Dosage Hemostatics Administration and Dosage Gentamicins Administration and Dosage Kidney Diseases Drug Therapy Dose-Response Relationship, Drug Taiwan Chromatography, High Pressure Liquid Blood Urea Nitrogen In Vivo Studies In Vitro Studies Descriptive Statistics One-Way Analysis of Variance P-Value Histocytochemistry Staining and Labeling ab: Aminoglycosides are widely used to treat infections; however, their applications are limited by nephrotoxicity. With the increase of antibiotic resistance, the use of aminoglycosides is inevitable. Low-molecular-weight chitosan (LMWC) has shown renal protective effects in dialysis patients. However, no study has evaluated LMWC for preventing aminoglycoside-induced nephrotoxicity or determined the mechanisms underlying the renal protective effects. In this study, LMWC (165 or 825 mg/kg/day) or metformin (100 mg/kg/day) was orally administered for 13 days to rats with nephropathy induced by gentamicin (GM), a kind of aminoglycoside (150 mg/kg/day i.p. for 6 days). Both LMCW doses improved renal function. Serum creatinine levels improved in rats treated with 165 and 825 mg/kg/day LMWC (from 2.14 ± 0.74 mg/dL to 1.26 ± 0.46 mg/dL and 0.69 ± 0.12 mg/dL, resp., P < 0.05). Blood urea nitrogen levels were also improved in these rats (from 73.73 ± 21.13 mg/dL to 58.70 ± 22.71 mg/dL and 28.82 ± 3.84 mg/dL, resp., P < 0.05). Additionally, renal tissue morphology improved after LMWC treatment, and accumulation of renal methylglyoxal, a damage factor associated with carbonyl stress, was reversed. These results show that LMWC prevents GM-induced renal toxicity via a carbonyl stress-dependent pathway. pubtype: Academic Journal doctype: equations & formulas pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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